Mortality factor 4-like protein 1 (MORF-related gene 15 protein) (Protein MSL3-1) (Transcription factor-like protein MRG15)
1_MAPKQ 6_ DPKPK 11_ FQEGE 16_ RVLCF 21_ HGPLL 26_ YEAKC 31_ VKVAI 36_ KDKQV 41_ KYFIH 46_ YSGWN 51_ KKSAV 56_ RPRRS 61_ EKSLK 66_ THEDI 71_ VALFP 76_ VPEGA 81_ PSVHH 86_ PLLTS 91_ SWDEW 96_ VPESR 101_ VLKYV 106_ DTNLQ 111_ KQREL 116_ QKANQ 121_ EQYAE 126_ GKMRG 131_ AAPGK 136_ KTSGL 141_ QQKNV 146_ EVKTK 151_ KNKQK 156_ TPGNG 161_ DGGST 166_ SETPQ 171_ PPRKK 176_ RARVD 181_ PTVEN 186_ EETFM 191_ NRVEV 196_ KVKIP 201_ EELKP 206_ WLVDD 211_ WDLIT 216_ RQKQL 221_ FYLPA 226_ KKNVD 231_ SILED 236_ YANYK 241_ KSRGN 246_ TDNKE 251_ YAVNE 256_ VVAGI 261_ KEYFN 266_ VMLGT 271_ QLLYK 276_ FERPQ 281_ YAEIL 286_ ADHPD 291_ APMSQ 296_ VYGAP 301_ HLLRL 306_ FVRIG 311_ AMLAY 316_ TPLDE 321_ KSLAL 326_ LLNYL 331_ HDFLK 336_ YLAKN 341_ SATLF 346_ SASDY 351_ EVAPP 356_EYHRK
1: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. As part of the SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:12391155, PubMed:14966270, PubMed:37137925). SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci