Nuclear RNA export factor 1 (Tip-associated protein) (Tip-associating protein) (mRNA export factor TAP)
1_MADEG 6_ KSYSE 11_ HDDER 16_ VNFPQ 21_ RKKKG 26_ RGPFR 31_ WKYGE 36_ GNRRS 41_ GRGGS 46_ GIRSS 51_ RLEED 56_ DGDVA 61_ MSDAQ 66_ DGPRV 71_ RYNPY 76_ TTRPN 81_ RRGDT 86_ WHDRD 91_ RIHVT 96_ VRRDR 101_ APPER 106_ GGAGT 111_ SQDGT 116_ SKNWF 121_ KITIP 126_ YGRKY 131_ DKAWL 136_ LSMIQ 141_ SKCSV 146_ PFTPI 151_ EFHYE 156_ NTRAQ 161_ FFVED 166_ ASTAS 171_ ALKAV 176_ NYKIL 181_ DRENR 186_ RISII 191_ INSSA 196_ PPHTI 201_ LNELK 206_ PEQVE 211_ QLKLI 216_ MSKRY 221_ DGSQQ 226_ ALDLK 231_ GLRSD 236_ PDLVA 241_ QNIDV 246_ VLNRR 251_ SCMAA 256_ TLRII 261_ EENIP 266_ ELLSL 271_ NLSNN 276_ RLYRL 281_ DDMSS 286_ IVQKA 291_ PNLKI 296_ LNLSG 301_ NELKS 306_ ERELD 311_ KIKGL 316_ KLEEL 321_ WLDGN 326_ SLCDT 331_ FRDQS 336_ TYISA 341_ IRERF 346_ PKLLR 351_ LDGHE 356_ LPPPI 361_ AFDVE 366_ APTTL 371_ PPCKG 376_ SYFGT 381_ ENLKS 386_ LVLHF 391_ LQQYY 396_ AIYDS 401_ GDRQG 406_ LLDAY 411_ HDGAC 416_ CSLSI 421_ PFIPQ 426_ NPARS 431_ SLAEY 436_ FKDSR 441_ NVKKL 446_ KDPTL 451_ RFRLL 456_ KHTRL 461_ NVVAF 466_ LNELP 471_ KTQHD 476_ VNSFV 481_ VDISA 486_ QTSTL 491_ LCFSV 496_ NGVFK 501_ EVDGK 506_ SRDSL 511_ RAFTR 516_ TFIAV 521_ PASNS 526_ GLCIV 531_ NDELF 536_ VRNAS 541_ SEEIQ 546_ RAFAM 551_ PAPTP 556_ SSSPV 561_ PTLSP 566_ EQQEM 571_ LQAFS 576_ TQSGM 581_ NLEWS 586_ QKCLQ 591_ DNNWD 596_ YTRSA 601_ QAFTH 606_ LKAKG 611_EIPEV
1: Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway) (PubMed:10924507). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex (PubMed:18364396, PubMed:19165146, PubMed:9660949). ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export (PubMed:18364396, PubMed:19165146, PubMed:9660949). Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244)