COP9 signalosome complex subunit 7a (SGN7a) (Signalosome subunit 7a) (Dermal papilla-derived protein 10) (JAB1-containing signalosome subunit 7a)
1_MSAEV 6_ KVTGQ 11_ NQEQF 16_ LLLAK 21_ SAKGA 26_ ALATL 31_ IHQVL 36_ EAPGV 41_ YVFGE 46_ LLDMP 51_ NVREL 56_ AESDF 61_ ASTFR 66_ LLTVF 71_ AYGTY 76_ ADYLA 81_ EARNL 86_ PPLTE 91_ AQKNK 96_ LRHLS 101_ VVTLA 106_ AKVKC 111_ IPYAV 116_ LLEAL 121_ ALRNV 126_ RQLED 131_ LVIEA 136_ VYADV 141_ LRGSL 146_ DQRNQ 151_ RLEVD 156_ YSIGR 161_ DIQRQ 166_ DLSAI 171_ ARTLQ 176_ EWCVG 181_ CEVVL 186_ SGIEE 191_ QVSRA 196_ NQHKE 201_ QQLGL 206_ KQQIE 211_ SEVAN 216_ LKKTI 221_ KVTTA 226_ AAAAA 231_ TSQDP 236_ EQHLT 241_ ELREP 246_ APGTN 251_ QRQPS 256_ KKASK 261_ GKGLR 266_GSAKI
1: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively