Homeobox expressed in ES cells 1 (Homeobox protein ANF) (hAnf)
1_MSPSL 6_ QEGAQ 11_ LGENK 16_ PSTCS 21_ FSIER 26_ ILGLD 31_ QKKDC 36_ VPLMK 41_ PHRPW 46_ ADTCS 51_ SSGKD 56_ GNLCL 61_ HVPNP 66_ PSGIS 71_ FPSVV 76_ DHPMP 81_ EERAS 86_ KYENY 91_ FSASE 96_ RLSLK 101_ RELSW 106_ YRGRR 111_ PRTAF 116_ TQNQI 121_ EVLEN 126_ VFRVN 131_ CYPGI 136_ DIRED 141_ LAQKL 146_ NLEED 151_ RIQIW 156_ FQNRR 161_ AKLKR 166_ SHRES 171_ QFLMA 176_KKNFN
1: Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5'-AGCTTGAGTCTAATTGAATTAACTGTAC-3'. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation