Mitochondrial dicarboxylate carrier (Solute carrier family 25 member 10)
1_MAAEA 6_ RVSRW 11_ YFGGL 16_ ASCGA 21_ ACCTH 26_ PLDLL 31_ KVHLQ 36_ TQQEV 41_ KLRMT 46_ GMALR 51_ VVRTD 56_ GILAL 61_ YSGLS 66_ ASLCR 71_ QMTYS 76_ LTRFA 81_ IYETV 86_ RDRVA 91_ KGSQG 96_ PLPFH 101_ EKVLL 106_ GSVSG 111_ LAGGF 116_ VGTPA 121_ DLVNV 126_ RMQND 131_ VKLPQ 136_ GQRRN 141_ YAHAL 146_ DGLYR 151_ VAREE 156_ GLRRL 161_ FSGAT 166_ MASSR 171_ GALVT 176_ VGQLS 181_ CYDQA 186_ KQLVL 191_ STGYL 196_ SDNIF 201_ THFVA 206_ SFIAG 211_ GCATF 216_ LCQPL 221_ DVLKT 226_ RLMNS 231_ KGEYQ 236_ GVFHC 241_ AVETA 246_ KLGPL 251_ AFYKG 256_ LVPAG 261_ IRLIP 266_ HTVLT 271_ FVFLE 276_ QLRKN 281_FGIKV
1: Catalyzes the electroneutral exchange or flux of physiologically important metabolites such as dicarboxylates (malonate, malate, succinate), inorganic sulfur-containing anions, and phosphate, across mitochondrial inner membrane (PubMed:29211846). Plays an important role in gluconeogenesis, fatty acid metabolism, urea synthesis, and sulfur metabolism, particularly in liver, by supplying the substrates for the different metabolic processes. Regulates fatty acid release from adipocytes, and contributes to systemic insulin sensitivity (By similarity)