Beta-1,4-galactosyltransferase 6 (Beta-1,4-GalTase 6) (Beta4Gal-T6) (b4Gal-T6) (EC 2.4.1.-) (Glucosylceramide beta-1,4-galactosyltransferase) (EC 2.4.1.274) (Lactosylceramide synthase) (LacCer synthase) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 6) (UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase) (UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 6)
1_MSVLR 6_ RMMRV 11_ SNRSL 16_ LAFIF 21_ FFSLS 26_ SSCLY 31_ FIYVA 36_ PGIAN 41_ TYLFM 46_ VQARG 51_ IMLRE 56_ NVKTI 61_ GHMIR 66_ LYTNK 71_ NSTLN 76_ GTDYP 81_ EGNNS 86_ SDYLV 91_ QTTTY 96_ LPENF 101_ TYSPY 106_ LPCPE 111_ KLPYM 116_ RGFLN 121_ VNVSE 126_ VSFDE 131_ IHQLF 136_ SKDLD 141_ IEPGG 146_ HWRPK 151_ DCKPR 156_ WKVAV 161_ LIPFR 166_ NRHEH 171_ LPIFF 176_ LHLIP 181_ MLQKQ 186_ RLEFA 191_ FYVIE 196_ QTGTQ 201_ PFNRA 206_ MLFNV 211_ GFKEA 216_ MKDSV 221_ WDCVI 226_ FHDVD 231_ HLPEN 236_ DRNYY 241_ GCGEM 246_ PRHFA 251_ AKLDK 256_ YMYIL 261_ PYKEF 266_ FGGVS 271_ GLTVE 276_ QFRKI 281_ NGFPN 286_ AFWGW 291_ GGEDD 296_ DLWNR 301_ VHYAG 306_ YNVTR 311_ PEGDL 316_ GKYKS 321_ IPHHH 326_ RGEVQ 331_ FLGRY 336_ KLLRY 341_ SKERQ 346_ YIDGL 351_ NNLIY 356_ RPKIL 361_ VDRLY 366_ TNISV 371_ NLMPE 376_LAPIE
1: Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (PubMed:1551920, PubMed:24498430, PubMed:3099851). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (By similarity)