Sodium/hydrogen exchanger 2 (Na(+)/H(+) exchanger 2) (NHE-2) (Solute carrier family 9 member 2)
1_MEPLG 6_ NWRSL 11_ RAPLP 16_ PMLLL 21_ LLLQV 26_ AGPVG 31_ ALAET 36_ LLNAP 41_ RAMGT 46_ SSSPP 51_ SPASV 56_ VAPGT 61_ TLFEE 66_ SRLPV 71_ FTLDY 76_ PHVQI 81_ PFEIT 86_ LWILL 91_ ASLAK 96_ IGFHL 101_ YHKLP 106_ TIVPE 111_ SCLLI 116_ MVGLL 121_ LGGII 126_ FGVDE 131_ KSPPA 136_ MKTDV 141_ FFLYL 146_ LPPIV 151_ LDAGY 156_ FMPTR 161_ PFFEN 166_ IGTIF 171_ WYAVV 176_ GTLWN 181_ SIGIG 186_ VSLFG 191_ ICQIE 196_ AFGLS 201_ DITLL 206_ QNLLF 211_ GSLIS 216_ AVDPV 221_ AVLAV 226_ FENIH 231_ VNEQL 236_ YILVF 241_ GESLL 246_ NDAVT 251_ VVLYN 256_ LFKSF 261_ CQMKT 266_ IETID 271_ VFAGI 276_ ANFFV 281_ VGIGG 286_ VLIGI 291_ FLGFI 296_ AAFTT 301_ RFTHN 306_ IRVIE 311_ PLFVF 316_ LYSYL 321_ SYITA 326_ EMFHL 331_ SGIMA 336_ ITACA 341_ MTMNK 346_ YVEEN 351_ VSQKS 356_ YTTIK 361_ YFMKM 366_ LSSVS 371_ ETLIF 376_ IFMGV 381_ STVGK 386_ NHEWN 391_ WAFVC 396_ FTLAF 401_ CLMWR 406_ ALGVF 411_ VLTQV 416_ INRFR 421_ TIPLT 426_ FKDQF 431_ IIAYG 436_ GLRGA 441_ ICFAL 446_ VFLLP 451_ AAVFP 456_ RKKLF 461_ ITAAI 466_ VVIFF 471_ TVFIL 476_ GITIR 481_ PLVEF 486_ LDVKR 491_ SNKKQ 496_ QAVSE 501_ EIYCR 506_ LFDHV 511_ KTGIE 516_ DVCGH 521_ WGHNF 526_ WRDKF 531_ KKFDD 536_ KYLRK 541_ LLIRE 546_ NQPKS 551_ SIVSL 556_ YKKLE 561_ IKHAI 566_ EMAET 571_ GMIST 576_ VPTFA 581_ SLNDC 586_ REEKI 591_ RKVTS 596_ SETDE 601_ IRELL 606_ SRNLY 611_ QIRQR 616_ TLSYN 621_ RHSLT 626_ ADTSE 631_ RQAKE 636_ ILIRR 641_ RHSLR 646_ ESIRK 651_ DSSLN 656_ REHRA 661_ STSTS 666_ RYLSL 671_ PKNTK 676_ LPEKL 681_ QKRRT 686_ ISIAD 691_ GNSSD 696_ SDADA 701_ GTTVL 706_ NLQPR 711_ ARRFL 716_ PEQFS 721_ KKSPQ 726_ SYKME 731_ WKNEV 736_ DVDSG 741_ RDMPS 746_ TPPTP 751_ HSREK 756_ GTQTS 761_ GLLQQ 766_ PLLSK 771_ DQSGS 776_ EREDS 781_ LTEGI 786_ PPKPP 791_ PRLVW 796_ RASEP 801_ GSRKA 806_RFGSE
1: Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) (PubMed:10444453). Major apical Na(+)/H(+) exchanger in the base of the colonic crypt. Controls in the colonic crypt intracellular pH (pHi) to direct colonic epithelial cell differentiation into the absorptive enterocyte lineage at the expense of the secretory lineage (By similarity)