DNA-(apurinic or apyrimidinic site) endonuclease 2 (EC 3.1.11.2) (AP endonuclease XTH2) (APEX nuclease 2) (APEX nuclease-like 2) (Apurinic-apyrimidinic endonuclease 2) (AP endonuclease 2)
1_MLRVV 6_ SWNIN 11_ GIRRP 16_ LQGVA 21_ NQEPS 26_ NCAAV 31_ AVGRI 36_ LDELD 41_ ADIVC 46_ LQETK 51_ VTRDA 56_ LTEPL 61_ AIVEG 66_ YNSYF 71_ SFSRN 76_ RSGYS 81_ GVATF 86_ CKDNA 91_ TPVAA 96_ EEGLS 101_ GLFAT 106_ QNGDV 111_ GCYGN 116_ MDEFT 121_ QEELR 126_ ALDSE 131_ GRALL 136_ TQHKI 141_ RTWEG 146_ KEKTL 151_ TLINV 156_ YCPHA 161_ DPGRP 166_ ERLVF 171_ KMRFY 176_ RLLQI 181_ RAEAL 186_ LAAGS 191_ HVIIL 196_ GDLNT 201_ AHRPI 206_ DHWDA 211_ VNLEC 216_ FEEDP 221_ GRKWM 226_ DSLLS 231_ NLGCQ 236_ SASHV 241_ GPFID 246_ SYRCF 251_ QPKQE 256_ GAFTC 261_ WSAVT 266_ GARHL 271_ NYGSR 276_ LDYVL 281_ GDRTL 286_ VIDTF 291_ QASFL 296_ LPEVM 301_ GSDHC 306_ PVGAV 311_ LSVSS 316_ VPAKQ 321_ CPPLC 326_ TRFLP 331_ EFAGT 336_ QLKIL 341_ RFLVP 346_ LEQSP 351_ VLEQS 356_ TLQHN 361_ NQTRV 366_ QTCQN 371_ KAQVR 376_ STRPQ 381_ PSQVG 386_ SSRGQ 391_ KNLKS 396_ YFQPS 401_ PSCPQ 406_ ASPDI 411_ ELPSL 416_ PLMSA 421_ LMTPK 426_ TPEEK 431_ AVAKV 436_ VKGQA 441_ KTSEA 446_ KDEKE 451_ LRTSF 456_ WKSVL 461_ AGPLR 466_ TPLCG 471_ GHREP 476_ CVMRT 481_ VKKPG 486_ PNLGR 491_ RFYMC 496_ ARPRG 501_ PPTDP 506_ SSRCN 511_FFLWS
1: Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents (PubMed:16687656). Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Also displays double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities (PubMed:16687656, PubMed:19443450, PubMed:32516598). Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially (PubMed:16687656, PubMed:19443450). Also exhibits 3'-5' exonuclease activity on a single nucleotide gap containing heteroduplex DNA and on blunt-ended substrates (PubMed:16687656). Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents (PubMed:16687656, PubMed:19443450). In the nucleus functions in the PCNA-dependent BER pathway (PubMed:11376153). Plays a role in reversing blocked 3' DNA ends, problematic lesions that preclude DNA synthesis (PubMed:32516598). Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes (By similarity). Required for proper cell cycle progression during proliferation of peripheral lymphocytes (By similarity)