Tripartite motif-containing protein 10 (B30-RING finger protein) (RING finger protein 9)
1_MASAA 6_ SVTSL 11_ ADEVN 16_ CPICQ 21_ GTLRE 26_ PVTID 31_ CGHNF 36_ CRACL 41_ TRYCE 46_ IPGPD 51_ LEESP 56_ TCPLC 61_ KEPFR 66_ PGSFR 71_ PNWQL 76_ ANVVE 81_ NIERL 86_ QLVST 91_ LGLGE 96_ EDVCQ 101_ EHGEK 106_ IYFFC 111_ EDDEM 116_ QLCVV 121_ CREAG 126_ EHATH 131_ TMRFL 136_ EDAAA 141_ PYREQ 146_ IHKCL 151_ KCLRK 156_ EREEI 161_ QEIQS 166_ RENKR 171_ MQVLL 176_ TQVST 181_ KRQQV 186_ ISEFA 191_ HLRKF 196_ LEEQQ 201_ SILLA 206_ QLESQ 211_ DGDIL 216_ RQRDE 221_ FDLLV 226_ AGEIC 231_ RFSAL 236_ IEELE 241_ EKNER 246_ PAREL 251_ LTDIR 256_ STLIR 261_ CETRK 266_ CRKPV 271_ AVSPE 276_ LGQRI 281_ RDFPQ 286_ QALPL 291_ QREMK 296_ MFLEK 301_ LCFEL 306_ DYEPA 311_ HISLD 316_ PQTSH 321_ PKLLL 326_ SEDHQ 331_ RAQFS 336_ YKWQN 341_ SPDNP 346_ QRFDR 351_ ATCVL 356_ AHTGI 361_ TGGRH 366_ TWVVS 371_ IDLAH 376_ GGSCT 381_ VGVVS 386_ EDVQR 391_ KGELR 396_ LRPEE 401_ GVWAV 406_ RLAWG 411_ FVSAL 416_ GSFPT 421_ RLTLK 426_ EQPRQ 431_ VRVSL 436_ DYEVG 441_ WVTFT 446_ NAVTR 451_ EPIYT 456_ FTASF 461_ TRKVI 466_ PFFGL 471_ WGRGS 476_SFSLS
1: E3 ligase that plays an essential role in the differentiation and survival of terminal erythroid cells. May directly bind to PTEN and promote its ubiquitination, resulting in its proteasomal degradation and activation of hypertrophic signaling (By similarity). In addition, plays a role in immune response regulation by repressing the phosphorylation of STAT1 and STAT2 in the interferon/JAK/STAT signaling pathway independent of its E3 ligase activity. Mechanistically, interacts with the intracellular domain of IFNAR1 and thereby inhibits the association between TYK2 and IFNAR1 (PubMed:33811647)