Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (EC 3.4.22.-) (MALT lymphoma-associated translocation) (Paracaspase)
1_MSLLG 6_ DPLQA 11_ LPPSA 16_ APTGP 21_ LLAPP 26_ AGATL 31_ NRLRE 36_ PLLRR 41_ LSELL 46_ DQAPE 51_ GRGWR 56_ RLAEL 61_ AGSRG 66_ RLRLS 71_ CLDLE 76_ QCSLK 81_ VLEPE 86_ GSPSL 91_ CLLKL 96_ MGEKG 101_ CTVTE 106_ LSDFL 111_ QAMEH 116_ TEVLQ 121_ LLSPP 126_ GIKIT 131_ VNPES 136_ KAVLA 141_ GQFVK 146_ LCCRA 151_ TGHPF 156_ VQYQW 161_ FKMNK 166_ EIPNG 171_ NTSEL 176_ IFNAV 181_ HVKDA 186_ GFYVC 191_ RVNNN 196_ FTFEF 201_ SQWSQ 206_ LDVCD 211_ IPESF 216_ QRSVD 221_ GVSES 226_ KLQIC 231_ VEPTS 236_ QKLMP 241_ GSTLV 246_ LQCVA 251_ VGSPI 256_ PHYQW 261_ FKNEL 266_ PLTHE 271_ TKKLY 276_ MVPYV 281_ DLEHQ 286_ GTYWC 291_ HVYND 296_ RDSQD 301_ SKKVE 306_ IIIGR 311_ TDEAV 316_ ECTED 321_ ELNNL 326_ GHPDN 331_ KEQTT 336_ DQPLA 341_ KDKVA 346_ LLIGN 351_ MNYRE 356_ HPKLK 361_ APLVD 366_ VYELT 371_ NLLRQ 376_ LDFKV 381_ VSLLD 386_ LTEYE 391_ MRNAV 396_ DEFLL 401_ LLDKG 406_ VYGLL 411_ YYAGH 416_ GYENF 421_ GNSFM 426_ VPVDA 431_ PNPYR 436_ SENCL 441_ CVQNI 446_ LKLMQ 451_ EKETG 456_ LNVFL 461_ LDMCR 466_ KRNDY 471_ DDTIP 476_ ILDAL 481_ KVTAN 486_ IVFGY 491_ ATCQG 496_ AEAFE 501_ IQHSG 506_ LANGI 511_ FMKFL 516_ KDRLL 521_ EDKKI 526_ TVLLD 531_ EVAED 536_ MGKCH 541_ LTKGK 546_ QALEI 551_ RSSLS 556_ EKRAL 561_ TDPIQ 566_ GTEYS 571_ AESLV 576_ RNLQW 581_ AKAHE 586_ LPESM 591_ CLKFD 596_ CGVQI 601_ QLGFA 606_ AEFSN 611_ VMIIY 616_ TSIVY 621_ KPPEI 626_ IMCDA 631_ YVTDF 636_ PLDLD 641_ IDPKD 646_ ANKGT 651_ PEETG 656_ SYLVS 661_ KDLPK 666_ HCLYT 671_ RLSSL 676_ QKLKE 681_ HLVFT 686_ VCLSY 691_ QYSGL 696_ EDTVE 701_ DKQEV 706_ NVGKP 711_ LIAKL 716_ DMHRG 721_ LGRKT 726_ CFQTC 731_ LMSNG 736_ PYQSS 741_ AATSG 746_ GAGHY 751_ HSLQD 756_ PFHGV 761_ YHSHP 766_ GNPSN 771_ VTPAD 776_ SCHCS 781_ RTPDA 786_ FISSF 791_ AHHAS 796_ CHFSR 801_ SNVPV 806_ ETTDE 811_ IPFSF 816_SDRLR
1: Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:11262391, PubMed:18264101, PubMed:24074955). Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion (PubMed:11262391, PubMed:18264101). Involved in the induction of T helper 17 cells (Th17) differentiation (PubMed:11262391, PubMed:18264101). Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (By similarity). Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation (PubMed:31133753). May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity (PubMed:14695475)