Klotho (EC 3.2.1.31) [Cleaved into: Klotho peptide]
1_MPASA 6_ PPRRP 11_ RPPPP 16_ SLSLL 21_ LVLLG 26_ LGGRR 31_ LRAEP 36_ GDGAQ 41_ TWARF 46_ SRPPA 51_ PEAAG 56_ LFQGT 61_ FPDGF 66_ LWAVG 71_ SAAYQ 76_ TEGGW 81_ QQHGK 86_ GASIW 91_ DTFTH 96_ HPLAP 101_ PGDSR 106_ NASLP 111_ LGAPS 116_ PLQPA 121_ TGDVA 126_ SDSYN 131_ NVFRD 136_ TEALR 141_ ELGVT 146_ HYRFS 151_ ISWAR 156_ VLPNG 161_ SAGVP 166_ NREGL 171_ RYYRR 176_ LLERL 181_ RELGV 186_ QPVVT 191_ LYHWD 196_ LPQRL 201_ QDAYG 206_ GWANR 211_ ALADH 216_ FRDYA 221_ ELCFR 226_ HFGGQ 231_ VKYWI 236_ TIDNP 241_ YVVAW 246_ HGYAT 251_ GRLAP 256_ GIRGS 261_ PRLGY 266_ LVAHN 271_ LLLAH 276_ AKVWH 281_ LYNTS 286_ FRPTQ 291_ GGQVS 296_ IALSS 301_ HWINP 306_ RRMTD 311_ HSIKE 316_ CQKSL 321_ DFVLG 326_ WFAKP 331_ VFIDG 336_ DYPES 341_ MKNNL 346_ SSILP 351_ DFTES 356_ EKKFI 361_ KGTAD 366_ FFALC 371_ FGPTL 376_ SFQLL 381_ DPHMK 386_ FRQLE 391_ SPNLR 396_ QLLSW 401_ IDLEF 406_ NHPQI 411_ FIVEN 416_ GWFVS 421_ GTTKR 426_ DDAKY 431_ MYYLK 436_ KFIME 441_ TLKAI 446_ KLDGV 451_ DVIGY 456_ TAWSL 461_ MDGFE 466_ WHRGY 471_ SIRRG 476_ LFYVD 481_ FLSQD 486_ KMLLP 491_ KSSAL 496_ FYQKL 501_ IEKNG 506_ FPPLP 511_ ENQPL 516_ EGTFP 521_ CDFAW 526_ GVVDN 531_ YIQVD 536_ TTLSQ 541_ FTDLN 546_ VYLWD 551_ VHHSK 556_ RLIKV 561_ DGVVT 566_ KKRKS 571_ YCVDF 576_ AAIQP 581_ QIALL 586_ QEMHV 591_ THFRF 596_ SLDWA 601_ LILPL 606_ GNQSQ 611_ VNHTI 616_ LQYYR 621_ CMASE 626_ LVRVN 631_ ITPVV 636_ ALWQP 641_ MAPNQ 646_ GLPRL 651_ LARQG 656_ AWENP 661_ YTALA 666_ FAEYA 671_ RLCFQ 676_ ELGHH 681_ VKLWI 686_ TMNEP 691_ YTRNM 696_ TYSAG 701_ HNLLK 706_ AHALA 711_ WHVYN 716_ EKFRH 721_ AQNGK 726_ ISIAL 731_ QADWI 736_ EPACP 741_ FSQKD 746_ KEVAE 751_ RVLEF 756_ DIGWL 761_ AEPIF 766_ GSGDY 771_ PWVMR 776_ DWLNQ 781_ RNNFL 786_ LPYFT 791_ EDEKK 796_ LIQGT 801_ FDFLA 806_ LSHYT 811_ TILVD 816_ SEKED 821_ PIKYN 826_ DYLEV 831_ QEMTD 836_ ITWLN 841_ SPSQV 846_ AVVPW 851_ GLRKV 856_ LNWLK 861_ FKYGD 866_ LPMYI 871_ ISNGI 876_ DDGLH 881_ AEDDQ 886_ LRVYY 891_ MQNYI 896_ NEALK 901_ AHILD 906_ GINLC 911_ GYFAY 916_ SFNDR 921_ TAPRF 926_ GLYRY 931_ AADQF 936_ EPKAS 941_ MKHYR 946_ KIIDS 951_ NGFPG 956_ PETLE 961_ RFCPE 966_ EFTVC 971_ TECSF 976_ FHTRK 981_ SLLAF 986_ IAFLF 991_ FASII 996_ SLSLI 1001_ FYYSK 1006_KGRRS
1: May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity)
2: The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling