Gamma-adducin (Adducin-like protein 70)
1_MSSDA 6_ SQGVI 11_ TTPPP 16_ PSMPH 21_ KERYF 26_ DRINE 31_ NDPEY 36_ IRERN 41_ MSPDL 46_ RQDFN 51_ MMEQR 56_ KRVTQ 61_ ILQSP 66_ AFRED 71_ LECLI 76_ QEQMK 81_ KGHNP 86_ TGLLA 91_ LQQIA 96_ DYIMA 101_ NSFSG 106_ FSSPP 111_ LSLGM 116_ VTPIN 121_ DLPGA 126_ DTSSY 131_ VKGEK 136_ LTRCK 141_ LASLY 146_ RLVDL 151_ FGWAH 156_ LANTY 161_ ISVRI 166_ SKEQD 171_ HIIII 176_ PRGLS 181_ FSEAT 186_ ASNLV 191_ KVNII 196_ GEVVD 201_ QGSTN 206_ LKIDH 211_ TGFSP 216_ HAAIY 221_ STRPD 226_ VKCVI 231_ HIHTL 236_ ATAAV 241_ SSMKC 246_ GILPI 251_ SQESL 256_ LLGDV 261_ AYYDY 266_ QGSLE 271_ EQEER 276_ IQLQK 281_ VLGPS 286_ CKVLV 291_ LRNHG 296_ VVALG 301_ ETLEE 306_ AFHYI 311_ FNVQL 316_ ACEIQ 321_ VQALA 326_ GAGGV 331_ DNLHV 336_ LDFQK 341_ YKAFT 346_ YTVAA 351_ SGGGG 356_ VNMGS 361_ HQKWK 366_ VGEIE 371_ FEGLM 376_ RTLDN 381_ LGYRT 386_ GYAYR 391_ HPLIR 396_ EKPRH 401_ KSDVE 406_ IPATV 411_ TAFSF 416_ EDDTV 421_ PLSPL 426_ KYMAQ 431_ RQQRE 436_ KTRWL 441_ NSPNT 446_ YMKVN 451_ VPEES 456_ RNGET 461_ SPRTK 466_ ITWMK 471_ AEDSS 476_ KVSGG 481_ TPIKI 486_ EDPNQ 491_ FVPLN 496_ TNPNE 501_ VLEKR 506_ NKIRE 511_ QNRYD 516_ LKTAG 521_ PQSQL 526_ LAGIV 531_ VDKPP 536_ STMQF 541_ EDDDH 546_ GPPAP 551_ PNPFS 556_ HLTEG 561_ ELEEY 566_ KRTIE 571_ RKQQG 576_ LEDAE 581_ QELLS 586_ DDASS 591_ VSQIQ 596_ SQTQS 601_ PQNVP 606_ EKLEE 611_ NHELF 616_ SKSFI 621_ SMEVP 626_ VMVVN 631_ GKDDM 636_ HDVED 641_ ELAKR 646_ VSRLS 651_ TSTTI 656_ ENIEI 661_ TIKSP 666_ EKIEE 671_ VLSPE 676_ GSPSK 681_ SPSKK 686_ KKKFR 691_ TPSFL 696_ KKNKK 701_KEKVE
1: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin (Probable). Involved in myogenic reactivity of the renal afferent arteriole (Af-art), renal interlobular arteries and middle cerebral artery (MCA) to increased perfusion pressure. Involved in regulation of potassium channels in the vascular smooth muscle cells (VSMCs) of the Af-art and MCA ex vivo. Involved in regulation of glomerular capillary pressure, glomerular filtration rate (GFR) and glomerular nephrin expression in response to hypertension. Involved in renal blood flow (RBF) autoregulation. Plays a role in podocyte structure and function. Regulates globular monomer actin (G-actin) and filamentous polymer actin (F-actin) ratios in the primary podocytes affecting actin cytoskeleton organization. Regulates expression of synaptopodin, RhoA, Rac1 and CDC42 in the renal cortex and the primary podocytes. Regulates expression of nephrin in the glomeruli and in the primary podocytes, expression of nephrin and podocinin in the renal cortex, and expression of focal adhesion proteins integrin alpha-3 and integrin beta-1 in the glomeruli. Involved in cell migration and cell adhesion of podocytes, and in podocyte foot process effacement. Regulates expression of profibrotics markers MMP2, MMP9, TGF beta-1, tubular tight junction protein E-cadherin, and mesenchymal markers vimentin and alpha-SMA (By similarity). Promotes the growth of neurites (By similarity)