Voltage-dependent calcium channel gamma-5 subunit (Neuronal voltage-gated calcium channel gamma-5 subunit) (Transmembrane AMPAR regulatory protein gamma-5) (TARP gamma-5)
1_MSACG 6_ RKALT 11_ LLSSV 16_ FAVCG 21_ LGLLG 26_ IAVST 31_ DYWLY 36_ LEEGV 41_ IVPQN 46_ QSTEI 51_ KMSLH 56_ SGLWR 61_ VCFLA 66_ GEERG 71_ RCFTI 76_ EYVMP 81_ MNTQL 86_ TSEST 91_ VNVLK 96_ MIRSA 101_ TPFPL 106_ VSLFF 111_ MFIGF 116_ ILNNI 121_ GHIRP 126_ HRTIL 131_ AFVSG 136_ IFFIL 141_ SGLSL 146_ VVGLV 151_ LYISS 156_ INDEM 161_ LNRTK 166_ DAETY 171_ FNYKY 176_ GWSFA 181_ FAAIS 186_ FLLTE 191_ SAGVM 196_ SVYLF 201_ MKRYT 206_ AEDMY 211_ RPHPG 216_ FYRPR 221_ LSNCS 226_ DYSGQ 231_ FLHPD 236_ AWVRG 241_ RSPSD 246_ ISSEA 251_ SLQMN 256_ SNYPA 261_ LLKCP 266_DYDQM
1: Regulates the gating properties of AMPA-selective glutamate receptors (AMPARs). Modulates their gating properties by accelerating their rates of activation, deactivation and desensitization. Displays subunit-specific AMPA receptor regulation. Shows specificity for GRIA1, GRIA4 and the long isoform of GRIA2. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity)