Leucine-rich repeat and WD repeat-containing protein 1 (Centromere protein 33) (CENP-33) (Origin recognition complex-associated protein) (ORC-associated protein) (ORCA)
1_MGPLS 6_ ARLLM 11_ QRGRP 16_ KSDRL 21_ GKIRS 26_ LDLSG 31_ LELLS 36_ EHLDP 41_ KLLCR 46_ LTQLQ 51_ ELDLS 56_ NNHLE 61_ TLPDN 66_ LGLSH 71_ LRVLR 76_ CANNQ 81_ LGDVT 86_ ALCQF 91_ PKLEE 96_ LSLEG 101_ NPFLT 106_ VNDNL 111_ KVSFL 116_ LPTLR 121_ KVNGK 126_ DASST 131_ YSQVE 136_ NLNRE 141_ LTSRV 146_ TAHWE 151_ KFMAT 156_ LGPEE 161_ EAEKA 166_ QADFV 171_ KSAVR 176_ DVRYG 181_ PESLS 186_ EFTQW 191_ RVRMI 196_ SEELV 201_ AASRT 206_ QVQKA 211_ NSPEK 216_ PPEAG 221_ AAHKP 226_ RARLA 231_ ALKRP 236_ DDVPL 241_ SLSPS 246_ KRACA 251_ SPSAQ 256_ VEGSP 261_ VAGSD 266_ GSQPA 271_ VKLEP 276_ LHFLQ 281_ CHSKN 286_ NSPQD 291_ LETQL 296_ WACAF 301_ EPAWE 306_ EGATS 311_ QTVAT 316_ CGGEA 321_ VCVID 326_ CQTGI 331_ VLHKY 336_ KAPGE 341_ EFFSV 346_ AWTAL 351_ MVVTQ 356_ AGHKK 361_ RWSVL 366_ AAAGL 371_ RGLVR 376_ LLHVR 381_ AGFCC 386_ GVIRA 391_ HKKAI 396_ ATLCF 401_ SPAHE 406_ THLFT 411_ ASYDK 416_ RIILW 421_ DIGVP 426_ NQDYE 431_ FQASQ 436_ LLTLD 441_ TTSIP 446_ LRLCP 451_ VASCP 456_ DARLL 461_ AGCEG 466_ GCCCW 471_ DVRLD 476_ QPQKR 481_ RVCEV 486_ EFVFS 491_ EGSEA 496_ SGRRV 501_ DGLAF 506_ VNEDI 511_ VASKG 516_ SGLGT 521_ ICLWS 526_ WRQTW 531_ GGRGS 536_ QSTVA 541_ VVVLA 546_ RLQWS 551_ STELA 556_ YFSLS 561_ ACPDK 566_ GIVLC 571_ GDEEG 576_ NVWLY 581_ DVSNI 586_ LKQPP 591_ LLPAA 596_ LQAPT 601_ QILKW 606_ PQPWA 611_ LGQVV 616_ TKTMV 621_ NTVVA 626_ NASFT 631_ YLTAL 636_ TDSNI 641_VAIWG
1: Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability