CCR4-NOT transcription complex subunit 8 (EC 3.1.13.4) (CAF1-like protein) (CALIFp) (CAF2) (CCR4-associated factor 8) (Caf1b)
1_MPAAL 6_ VENSQ 11_ VICEV 16_ WASNL 21_ EEEMR 26_ KIREI 31_ VLSYS 36_ YIAMD 41_ TEFPG 46_ VVVRP 51_ IGEFR 56_ SSIDY 61_ QYQLL 66_ RCNVD 71_ LLKII 76_ QLGLT 81_ FTNEK 86_ GEYPS 91_ GINTW 96_ QFNFK 101_ FNLTE 106_ DMYSQ 111_ DSIDL 116_ LANSG 121_ LQFQK 126_ HEEEG 131_ IDTLH 136_ FAELL 141_ MTSGV 146_ VLCDN 151_ VKWLS 156_ FHSGY 161_ DFGYM 166_ VKLLT 171_ DSRLP 176_ EEEHE 181_ FFHIL 186_ NLFFP 191_ SIYDV 196_ KYLMK 201_ SCKNL 206_ KGGLQ 211_ EVADQ 216_ LDLQR 221_ IGRQH 226_ QAGSD 231_ SLLTG 236_ MAFFR 241_ MKELF 246_ FEDSI 251_ DDAKY 256_ CGRLY 261_ GLGTG 266_ VAQKQ 271_ NEDVD 276_ SAQEK 281_ MSILA 286_IINNM
1: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex also seems to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity