Regulator of G-protein signaling 17 (RGS17)
1_MRKRQ 6_ QSQNE 11_ GTPAV 16_ SQAPG 21_ NQRPN 26_ NTCCF 31_ CWCCC 36_ CSCSC 41_ LTVRN 46_ EERGE 51_ NAGRP 56_ THTTK 61_ MESIQ 66_ VLEEC 71_ QNPTA 76_ EEVLS 81_ WSQNF 86_ DKMMK 91_ APAGR 96_ NLFRE 101_ FLRTE 106_ YSEEN 111_ LLFWL 116_ ACEDL 121_ KKEQN 126_ KKVIE 131_ EKARM 136_ IYEDY 141_ ISILS 146_ PKEVS 151_ LDSRV 156_ REVIN 161_ RNLLD 166_ PNPHM 171_ YEDAQ 176_ LQIYT 181_ LMHRD 186_ SFPRF 191_ LNSQI 196_ YKSFV 201_ESTAG
1: Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:15096504). Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity)