Ubiquitin thioesterase ZRANB1 (EC 3.4.19.12) (TRAF-binding domain-containing protein) (hTrabid) (Zinc finger Ran-binding domain-containing protein 1)
1_MSERG 6_ IKWAC 11_ EYCTY 16_ ENWPS 21_ AIKCT 26_ MCRAQ 31_ RPSGT 36_ IITED 41_ PFKSG 46_ SSDVG 51_ RDWDP 56_ SSTEG 61_ GSSPL 66_ ICPDS 71_ SARPR 76_ VKSSY 81_ SMENA 86_ NKWSC 91_ HMCTY 96_ LNWPR 101_ AIRCT 106_ QCLSQ 111_ RRTRS 116_ PTESP 121_ QSSGS 126_ GSRPV 131_ AFSVD 136_ PCEEY 141_ NDRNK 146_ LNTRT 151_ QHWTC 156_ SVCTY 161_ ENWAK 166_ AKRCV 171_ VCDHP 176_ RPNNI 181_ EAIEL 186_ AETEE 191_ ASSII 196_ NEQDR 201_ ARWRG 206_ SCSSG 211_ NSQRR 216_ SPPAT 221_ KRDSE 226_ VKMDF 231_ QRIEL 236_ AGAVG 241_ SKEEL 246_ EVDFK 251_ KLKQI 256_ KNRMK 261_ KTDWL 266_ FLNAC 271_ VGVVE 276_ GDLAA 281_ IEAYK 286_ SSGGD 291_ IARQL 296_ TADEV 301_ RLLNR 306_ PSAFD 311_ VGYTL 316_ VHLAI 321_ RFQRQ 326_ DMLAI 331_ LLTEV 336_ SQQAA 341_ KCIPA 346_ MVCPE 351_ LTEQI 356_ RREIA 361_ ASLHQ 366_ RKGDF 371_ ACYFL 376_ TDLVT 381_ FTLPA 386_ DIEDL 391_ PPTVQ 396_ EKLFD 401_ EVLDR 406_ DVQKE 411_ LEEES 416_ PIINW 421_ SLELA 426_ TRLDS 431_ RLYAL 436_ WNRTA 441_ GDCLL 446_ DSVLQ 451_ ATWGI 456_ YDKDS 461_ VLRKA 466_ LHDSL 471_ HDCSH 476_ WFYTR 481_ WKDWE 486_ SWYSQ 491_ SFGLH 496_ FSLRE 501_ EQWQE 506_ DWAFI 511_ LSLAS 516_ QPGAS 521_ LEQTH 526_ IFVLA 531_ HILRR 536_ PIIVY 541_ GVKYY 546_ KSFRG 551_ ETLGY 556_ TRFQG 561_ VYLPL 566_ LWEQS 571_ FCWKS 576_ PIALG 581_ YTRGH 586_ FSALV 591_ AMEND 596_ GYGNR 601_ GAGAN 606_ LNTDD 611_ DVTIT 616_ FLPLV 621_ DSERK 626_ LLHVH 631_ FLSAQ 636_ ELGNE 641_ EQQEK 646_ LLREW 651_ LDCCV 656_ TEGGV 661_ LVAMQ 666_ KSSRR 671_ RNHPL 676_ VTQMV 681_ EKWLD 686_ RYRQI 691_ RPCTS 696_ LSDGE 701_EDEDD
1: Ubiquitin thioesterase, which specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin (PubMed:22157957, PubMed:23827681, PubMed:25752573, PubMed:25752577). Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones (PubMed:18281465). Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription (PubMed:18281465). Acts as a regulator of autophagy by mediating deubiquitination of PIK3C3/VPS34, thereby promoting autophagosome maturation (PubMed:33637724). Plays a role in the regulation of cell morphology and cytoskeletal organization (PubMed:21834987). Required in the stress fiber dynamics and cell migration (PubMed:21834987)