5'-AMP-activated protein kinase subunit gamma-3 (AMPK gamma3) (AMPK subunit gamma-3)
1_MEPGL 6_ EHALR 11_ RTPSW 16_ SSLGG 21_ SEHQE 26_ MSFLE 31_ QENSS 36_ SWPSP 41_ AVTSS 46_ SERIR 51_ GKRRA 56_ KALRW 61_ TRQKS 66_ VEEGE 71_ PPGQG 76_ EGPRS 81_ RPAAE 86_ STGLE 91_ ATFPK 96_ TTPLA 101_ QADPA 106_ GVGTP 111_ PTGWD 116_ CLPSD 121_ CTASA 126_ AGSST 131_ DDVEL 136_ ATEFP 141_ ATEAW 146_ ECELE 151_ GLLEE 156_ RPALC 161_ LSPQA 166_ PFPKL 171_ GWDDE 176_ LRKPG 181_ AQIYM 186_ RFMQE 191_ HTCYD 196_ AMATS 201_ SKLVI 206_ FDTML 211_ EIKKA 216_ FFALV 221_ ANGVR 226_ AAPLW 231_ DSKKQ 236_ SFVGM 241_ LTITD 246_ FILVL 251_ HRYYR 256_ SPLVQ 261_ IYEIE 266_ QHKIE 271_ TWREI 276_ YLQGC 281_ FKPLV 286_ SISPN 291_ DSLFE 296_ AVYTL 301_ IKNRI 306_ HRLPV 311_ LDPVS 316_ GNVLH 321_ ILTHK 326_ RLLKF 331_ LHIFG 336_ SLLPR 341_ PSFLY 346_ RTIQD 351_ LGIGT 356_ FRDLA 361_ VVLET 366_ APILT 371_ ALDIF 376_ VDRRV 381_ SALPV 386_ VNECG 391_ QVVGL 396_ YSRFD 401_ VIHLA 406_ AQQTY 411_ NHLDM 416_ SVGEA 421_ LRQRT 426_ LCLEG 431_ VLSCQ 436_ PHESL 441_ GEVID 446_ RIARE 451_ QVHRL 456_ VLVDE 461_ TQHLL 466_ GVVSL 471_ SDILQ 476_ ALVLS 481_PAGID
1: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:14722619, PubMed:17878938, PubMed:24563466). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. AMPK also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. The AMPK gamma3 subunit is a non-catalytic subunit with a regulatory role in muscle energy metabolism (PubMed:17878938). It mediates binding to AMP, ADP and ATP, leading to AMPK activation or inhibition: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive