5'-AMP-activated protein kinase subunit gamma-2 (AMPK gamma2) (AMPK subunit gamma-2) (H91620p)
1_MGSAV 6_ MDTKK 11_ KKDVS 16_ SPGGS 21_ GGKKN 26_ ASQKR 31_ RSLRV 36_ HIPDL 41_ SSFAM 46_ PLLDG 51_ DLEGS 56_ GKHSS 61_ RKVDS 66_ PFGPG 71_ SPSKG 76_ FFSRG 81_ PQPRP 86_ SSPMS 91_ APVRP 96_ KTSPG 101_ SPKTV 106_ FPFSY 111_ QESPP 116_ RSPRR 121_ MSFSG 126_ IFRSS 131_ SKESS 136_ PNSNP 141_ ATSPG 146_ GIRFF 151_ SRSRK 156_ TSGLS 161_ SSPST 166_ PTQVT 171_ KQHTF 176_ PLESY 181_ KHEPE 186_ RLENR 191_ IYASS 196_ SPPDT 201_ GQRFC 206_ PSSFQ 211_ SPTRP 216_ PLASP 221_ THYAP 226_ SKAAA 231_ LAAAL 236_ GPAEA 241_ GMLEK 246_ LEFED 251_ EAVED 256_ SESGV 261_ YMRFM 266_ RSHKC 271_ YDIVP 276_ TSSKL 281_ VVFDT 286_ TLQVK 291_ KAFFA 296_ LVANG 301_ VRAAP 306_ LWESK 311_ KQSFV 316_ GMLTI 321_ TDFIN 326_ ILHRY 331_ YKSPM 336_ VQIYE 341_ LEEHK 346_ IETWR 351_ ELYLQ 356_ ETFKP 361_ LVNIS 366_ PDASL 371_ FDAVY 376_ SLIKN 381_ KIHRL 386_ PVIDP 391_ ISGNA 396_ LYILT 401_ HKRIL 406_ KFLQL 411_ FMSDM 416_ PKPAF 421_ MKQNL 426_ DELGI 431_ GTYHN 436_ IAFIH 441_ PDTPI 446_ IKALN 451_ IFVER 456_ RISAL 461_ PVVDE 466_ SGKVV 471_ DIYSK 476_ FDVIN 481_ LAAEK 486_ TYNNL 491_ DITVT 496_ QALQH 501_ RSQYF 506_ EGVVK 511_ CNKLE 516_ ILETI 521_ VDRIV 526_ RAEVH 531_ RLVVV 536_ NEADS 541_ IVGII 546_ SLSDI 551_ LQALI 556_ LTPAG 561_AKQKE
1: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:14722619, PubMed:24563466). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:14722619, PubMed:24563466). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:14722619, PubMed:24563466). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:14722619, PubMed:24563466). Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits (PubMed:14722619, PubMed:24563466). ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit (PubMed:14722619, PubMed:24563466). ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (PubMed:14722619, PubMed:24563466)