Lysine-specific demethylase 5B (EC 1.14.11.67) (Cancer/testis antigen 31) (CT31) (Histone demethylase JARID1B) (Jumonji/ARID domain-containing protein 1B) (PLU-1) (Retinoblastoma-binding protein 2 homolog 1) (RBP2-H1) ([histone H3]-trimethyl-L-lysine(4) demethylase 5B)
1_MEAAT 6_ TLHPG 11_ PRPAL 16_ PLGGP 21_ GPLGE 26_ FLPPP 31_ ECPVF 36_ EPSWE 41_ EFADP 46_ FAFIH 51_ KIRPI 56_ AEQTG 61_ ICKVR 66_ PPPDW 71_ QPPFA 76_ CDVDK 81_ LHFTP 86_ RIQRL 91_ NELEA 96_ QTRVK 101_ LNFLD 106_ QIAKY 111_ WELQG 116_ STLKI 121_ PHVER 126_ KILDL 131_ FQLNK 136_ LVAEE 141_ GGFAV 146_ VCKDR 151_ KWTKI 156_ ATKMG 161_ FAPGK 166_ AVGSH 171_ IRGHY 176_ ERILN 181_ PYNLF 186_ LSGDS 191_ LRCLQ 196_ KPNLT 201_ TDTKD 206_ KEYKP 211_ HDIPQ 216_ RQSVQ 221_ PSETC 226_ PPARR 231_ AKRMR 236_ AEAMN 241_ IKIEP 246_ EETTE 251_ ARTHN 256_ LRRRM 261_ GCPTP 266_ KCENE 271_ KEMKS 276_ SIKQE 281_ PIERK 286_ DYIVE 291_ NEKEK 296_ PKSRS 301_ KKATN 306_ AVDLY 311_ VCLLC 316_ GSGND 321_ EDRLL 326_ LCDGC 331_ DDSYH 336_ TFCLI 341_ PPLHD 346_ VPKGD 351_ WRCPK 356_ CLAQE 361_ CSKPQ 366_ EAFGF 371_ EQAAR 376_ DYTLR 381_ TFGEM 386_ ADAFK 391_ SDYFN 396_ MPVHM 401_ VPTEL 406_ VEKEF 411_ WRLVS 416_ TIEED 421_ VTVEY 426_ GADIA 431_ SKEFG 436_ SGFPV 441_ RDGKI 446_ KLSPE 451_ EEEYL 456_ DSGWN 461_ LNNMP 466_ VMEQS 471_ VLAHI 476_ TADIC 481_ GMKLP 486_ WLYVG 491_ MCFSS 496_ FCWHI 501_ EDHWS 506_ YSINY 511_ LHWGE 516_ PKTWY 521_ GVPGY 526_ AAEQL 531_ ENVMK 536_ KLAPE 541_ LFVSQ 546_ PDLLH 551_ QLVTI 556_ MNPNT 561_ LMTHE 566_ VPVYR 571_ TNQCA 576_ GEFVI 581_ TFPRA 586_ YHSGF 591_ NQGFN 596_ FAEAV 601_ NFCTV 606_ DWLPL 611_ GRQCV 616_ EHYRL 621_ LHRYC 626_ VFSHD 631_ EMICK 636_ MASKA 641_ DVLDV 646_ VVAST 651_ VQKDM 656_ AIMIE 661_ DEKAL 666_ RETVR 671_ KLGVI 676_ DSERM 681_ DFELL 686_ PDDER 691_ QCVKC 696_ KTTCF 701_ MSAIS 706_ CSCKP 711_ GLLVC 716_ LHHVK 721_ ELCSC 726_ PPYKY 731_ KLRYR 736_ YTLDD 741_ LYPMM 746_ NALKL 751_ RAESY 756_ NEWAL 761_ NVNEA 766_ LEAKI 771_ NKKKS 776_ LVSFK 781_ ALIEE 786_ SEMKK 791_ FPDND 796_ LLRHL 801_ RLVTQ 806_ DAEKC 811_ ASVAQ 816_ QLLNG 821_ KRQTR 826_ YRSGG 831_ GKSQN 836_ QLTVN 841_ ELRQF 846_ VTQLY 851_ ALPCV 856_ LSQTP 861_ LLKDL 866_ LNRVE 871_ DFQQH 876_ SQKLL 881_ SEETP 886_ SAAEL 891_ QDLLD 896_ VSFEF 901_ DVELP 906_ QLAEM 911_ RIRLE 916_ QARWL 921_ EEVQQ 926_ ACLDP 931_ SSLTL 936_ DDMRR 941_ LIDLG 946_ VGLAP 951_ YSAVE 956_ KAMAR 961_ LQELL 966_ TVSEH 971_ WDDKA 976_ KSLLK 981_ ARPRH 986_ SLNSL 991_ ATAVK 996_ EIEEI 1001_ PAYLP 1006_ NGAAL 1011_ KDSVQ 1016_ RARDW 1021_ LQDVE 1026_ GLQAG 1031_ GRVPV 1036_ LDTLI 1041_ ELVTR 1046_ GRSIP 1051_ VHLNS 1056_ LPRLE 1061_ TLVAE 1066_ VQAWK 1071_ ECAVN 1076_ TFLTE 1081_ NSPYS 1086_ LLEVL 1091_ CPRCD 1096_ IGLLG 1101_ LKRKQ 1106_ RKLKE 1111_ PLPNG 1116_ KKKST 1121_ KLESL 1126_ SDLER 1131_ ALTES 1136_ KETAS 1141_ AMATL 1146_ GEARL 1151_ REMEA 1156_ LQSLR 1161_ LANEG 1166_ KLLSP 1171_ LQDVD 1176_ IKICL 1181_ CQKAP 1186_ AAPMI 1191_ QCELC 1196_ RDAFH 1201_ TSCVA 1206_ VPSIS 1211_ QGLRI 1216_ WLCPH 1221_ CRRSE 1226_ KPPLE 1231_ KILPL 1236_ LASLQ 1241_ RIRVR 1246_ LPEGD 1251_ ALRYM 1256_ IERTV 1261_ NWQHR 1266_ AQQLL 1271_ SSGNL 1276_ KFVQD 1281_ RVGSG 1286_ LLYSR 1291_ WQASA 1296_ GQVSD 1301_ TNKVS 1306_ QPPGT 1311_ TSFSL 1316_ PDDWD 1321_ NRTSY 1326_ LHSPF 1331_ STGRS 1336_ CIPLH 1341_ GVSPE 1346_ VNELL 1351_ MEAQL 1356_ LQVSL 1361_ PEIQE 1366_ LYQTL 1371_ LAKPS 1376_ PAQQT 1381_ DRSSP 1386_ VRPSS 1391_ EKNDC 1396_ CRGKR 1401_ DGINS 1406_ LERKL 1411_ KRRLE 1416_ REGLS 1421_ SERWE 1426_ RVKKM 1431_ RTPKK 1436_ KKIKL 1441_ SHPKD 1446_ MNNFK 1451_ LERER 1456_ SYELV 1461_ RSAET 1466_ HSLPS 1471_ DTSYS 1476_ EQEDS 1481_ EDEDA 1486_ ICPAV 1491_ SCLQP 1496_ EGDEV 1501_ DWVQC 1506_ DGSCN 1511_ QWFHQ 1516_ VCVGV 1521_ SPEMA 1526_ EKEDY 1531_ ICVRC 1536_TVKDA
1: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:24952722, PubMed:27214403, PubMed:28262558). Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5 (PubMed:24952722). In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity)