Neuronal acetylcholine receptor subunit alpha-9 (Nicotinic acetylcholine receptor subunit alpha-9) (NACHR alpha-9)
1_MNWSH 6_ SCISF 11_ CWIYF 16_ AASRL 21_ RAAET 26_ ADGKY 31_ AQKLF 36_ NDLFE 41_ DYSNA 46_ LRPVE 51_ DTDKV 56_ LNVTL 61_ QITLS 66_ QIKDM 71_ DERNQ 76_ ILTAY 81_ LWIRQ 86_ IWHDA 91_ YLTWD 96_ RDQYD 101_ GLDSI 106_ RIPSD 111_ LVWRP 116_ DIVLY 121_ NKADD 126_ ESSEP 131_ VNTNV 136_ VLRYD 141_ GLITW 146_ DAPAI 151_ TKSSC 156_ VVDVT 161_ YFPFD 166_ NQQCN 171_ LTFGS 176_ WTYNG 181_ NQVDI 186_ FNALD 191_ SGDLS 196_ DFIED 201_ VEWEV 206_ HGMPA 211_ VKNVI 216_ SYGCC 221_ SEPYP 226_ DVTFT 231_ LLLKR 236_ RSSFY 241_ IVNLL 246_ IPCVL 251_ ISFLA 256_ PLSFY 261_ LPAAS 266_ GEKVS 271_ LGVTI 276_ LLAMT 281_ VFQLM 286_ VAEIM 291_ PASEN 296_ VPLIG 301_ KYYIA 306_ TMALI 311_ TASTA 316_ LTIMV 321_ MNIHF 326_ CGAEA 331_ RPVPH 336_ WARVV 341_ ILKYM 346_ SRVLF 351_ VYDVG 356_ ESCLS 361_ PHHSR 366_ ERDHL 371_ TKVYS 376_ KLPES 381_ NLKAA 386_ RNKDL 391_ SRKKD 396_ MNKRL 401_ KNDLG 406_ CQGKN 411_ PQEAE 416_ SYCAQ 421_ YKVLT 426_ RNIEY 431_ IAKCL 436_ KDHKA 441_ TNSKG 446_ SEWKK 451_ VAKVI 456_ DRFFM 461_ WIFFI 466_ MVFVM 471_TILII
1: Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:11752216, PubMed:18723036, PubMed:25282151). Forms either homopentamers or heteropentamers with CHRNA10. Expressed in the inner ear, in sympathetic neurons and in other non-neuronal cells, such as skin keratinocytes and lymphocytes (PubMed:11752216, PubMed:18723036). nAChR formed by CHRNA9:CHRNA10 mediate central nervous system control of auditory and vestibular sensory processing. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed:11752216, PubMed:25282151). In the ear, mediates synaptic transmission between efferent olivocochlear fibers and hair cells of the cochlea, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma (By similarity). May also regulate keratinocyte adhesion (PubMed:11021840, PubMed:11752216, PubMed:25282151)