CMRF35-like molecule 8 (CLM-8) (CD300 antigen-like family member A) (CMRF-35-H9) (CMRF35-H9) (CMRF35-H) (IRC1/IRC2) (Immunoglobulin superfamily member 12) (IgSF12) (Inhibitory receptor protein 60) (IRp60) (NK inhibitory receptor) (CD antigen CD300a)
1_MWLPW 6_ ALLLL 11_ WVPGC 16_ FALSK 21_ CRTVA 26_ GPVGG 31_ SLSVQ 36_ CPYEK 41_ EHRTL 46_ NKYWC 51_ RPPQI 56_ FLCDK 61_ IVETK 66_ GSAGK 71_ RNGRV 76_ SIRDS 81_ PANLS 86_ FTVTL 91_ ENLTE 96_ EDAGT 101_ YWCGV 106_ DTPWL 111_ RDFHD 116_ PVVEV 121_ EVSVF 126_ PASTS 131_ MTPAS 136_ ITAAK 141_ TSTIT 146_ TAFPP 151_ VSSTT 156_ LFAVG 161_ ATHSA 166_ SIQEE 171_ TEEVV 176_ NSQLP 181_ LLLSL 186_ LALLL 191_ LLLVG 196_ ASLLA 201_ WRMFQ 206_ KWIKA 211_ GDHSE 216_ LSQNP 221_ KQAAT 226_ QSELH 231_ YANLE 236_ LLMWP 241_ LQEKP 246_ APPRE 251_ VEVEY 256_ STVAS 261_ PREEL 266_ HYASV 271_ VFDSN 276_ TNRIA 281_ AQRPR 286_ EEEPD 291_SDYSV
1: Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:10746781, PubMed:16339535, PubMed:9701027). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (PubMed:22043923)