LIM domain-containing protein 1
1_MDKYD 6_ DLGLE 11_ ASKFI 16_ EDLNM 21_ YEASK 26_ DGLFR 31_ VDKGA 36_ GNNPE 41_ FEETR 46_ RVFAT 51_ KMAKI 56_ HLQQQ 61_ QQQLL 66_ QEETL 71_ PRGSR 76_ GPVNG 81_ GGRLG 86_ PQARW 91_ EVVGS 96_ KLTVD 101_ GAAKP 106_ PLAAS 111_ TGAPG 116_ AVTTL 121_ AAGQP 126_ PYPPQ 131_ EQRSR 136_ PYLHG 141_ TRHGS 146_ QDCGS 151_ RESLA 156_ TSEMS 161_ AFHQP 166_ GPCED 171_ PSCLT 176_ HGDYY 181_ DNLSL 186_ ASPKW 191_ GDKPG 196_ VSPSI 201_ GLSVG 206_ SGWPS 211_ SPGSD 216_ PPLPK 221_ PCGDH 226_ PLNHR 231_ QLSLS 236_ SSRSS 241_ EGSLG 246_ GQNSG 251_ IGGRS 256_ SEKPT 261_ GLWST 266_ ASSQR 271_ VSPGL 276_ PSPNL 281_ ENGAP 286_ AVGPV 291_ QPRTP 296_ SVSAP 301_ LALSC 306_ PRQGG 311_ LPRSN 316_ SGLGG 321_ EVSGV 326_ MSKPN 331_ VDPQP 336_ WFQDG 341_ PKSYL 346_ SSSAP 351_ SSSPA 356_ GLDGS 361_ QQGAV 366_ PGLGP 371_ KPGCT 376_ DLGTG 381_ PKLSP 386_ TSLVH 391_ PVMST 396_ LPELS 401_ CKEGP 406_ LGWSS 411_ DGSLG 416_ SVLLD 421_ SPSSP 426_ RVRLP 431_ CQPLV 436_ PGPEL 441_ RPSAA 446_ ELKLE 451_ ALTQR 456_ LEREM 461_ DAHPK 466_ ADYFG 471_ ACVKC 476_ SKGVF 481_ GAGQA 486_ CQAMG 491_ NLYHD 496_ TCFTC 501_ AACSR 506_ KLRGK 511_ AFYFV 516_ NGKVF 521_ CEEDF 526_ LYSGF 531_ QQSAD 536_ RCFLC 541_ GHLIM 546_ DMILQ 551_ ALGKS 556_ YHPGC 561_ FRCVI 566_ CNECL 571_ DGVPF 576_ TVDSE 581_ NKIYC 586_ VRDYH 591_ KVLAP 596_ KCAAC 601_ GLPIL 606_ PPEGS 611_ DETIR 616_ VVSMD 621_ RDYHV 626_ ECYHC 631_ EDCGL 636_ ELNDE 641_ DGHRC 646_ YPLED 651_ HLFCH 656_ SCHVK 661_ RLEKR 666_ PSSTA 671_LHQHH
1: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation