DNA polymerase lambda (Pol Lambda) (EC 2.7.7.7) (EC 4.2.99.-) (DNA polymerase beta-2) (Pol beta2) (DNA polymerase kappa)
1_MDPRG 6_ ILKAF 11_ PKRQK 16_ IHADA 21_ SSKVL 26_ AKIPR 31_ REEGE 36_ EAEEW 41_ LSSLR 46_ AHVVR 51_ TGIGR 56_ ARAEL 61_ FEKQI 66_ VQHGG 71_ QLCPA 76_ QGPGV 81_ THIVV 86_ DEGMD 91_ YERAL 96_ RLLRL 101_ PQLPP 106_ GAQLV 111_ KSAWL 116_ SLCLQ 121_ ERRLV 126_ DVAGF 131_ SIFIP 136_ SRYLD 141_ HPQPS 146_ KAEQD 151_ ASIPP 156_ GTHEA 161_ LLQTA 166_ LSPPP 171_ PPTRP 176_ VSPPQ 181_ KAKEA 186_ PNTQA 191_ QPISD 196_ DEASD 201_ GEETQ 206_ VSAAD 211_ LEALI 216_ SGHYP 221_ TSLEG 226_ DCEPS 231_ PAPAV 236_ LDKWV 241_ CAQPS 246_ SQKAT 251_ NHNLH 256_ ITEKL 261_ EVLAK 266_ AYSVQ 271_ GDKWR 276_ ALGYA 281_ KAINA 286_ LKSFH 291_ KPVTS 296_ YQEAC 301_ SIPGI 306_ GKRMA 311_ EKIIE 316_ ILESG 321_ HLRKL 326_ DHISE 331_ SVPVL 336_ ELFSN 341_ IWGAG 346_ TKTAQ 351_ MWYQQ 356_ GFRSL 361_ EDIRS 366_ QASLT 371_ TQQAI 376_ GLKHY 381_ SDFLE 386_ RMPRE 391_ EATEI 396_ EQTVQ 401_ KAAQA 406_ FNSGL 411_ LCVAC 416_ GSYRR 421_ GKATC 426_ GDVDV 431_ LITHP 436_ DGRSH 441_ RGIFS 446_ RLLDS 451_ LRQEG 456_ FLTDD 461_ LVSQE 466_ ENGQQ 471_ QKYLG 476_ VCRLP 481_ GPGRR 486_ HRRLD 491_ IIVVP 496_ YSEFA 501_ CALLY 506_ FTGSA 511_ HFNRS 516_ MRALA 521_ KTKGM 526_ SLSEH 531_ ALSTA 536_ VVRNT 541_ HGCKV 546_ GPGRV 551_ LPTPT 556_ EKDVF 561_ RLLGL 566_PYREP
1: DNA polymerase that functions in several pathways of DNA repair (PubMed:11457865, PubMed:19806195, PubMed:20693240, PubMed:30250067). Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA (PubMed:11457865, PubMed:19806195). Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination (PubMed:19806195, PubMed:20693240, PubMed:30250067). Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities (PubMed:10887191, PubMed:10982892, PubMed:12809503, PubMed:14627824, PubMed:15537631, PubMed:19806195). Also has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity (PubMed:11457865, PubMed:19806195)