Calcium channel flower homolog (Calcium channel flower domain-containing protein 1)
1_MSSSG 6_ GAPGA 11_ SASSA 16_ PPAQE 21_ EGMTW 26_ WYRWL 31_ CRLSG 36_ VLGAV 41_ SCAIS 46_ GLFNC 51_ ITIHP 56_ LNIAA 61_ GVWMI 66_ MNAFI 71_ LLLCE 76_ APFCC 81_ QFIEF 86_ ANTVA 91_ EKVDR 96_ LRSWQ 101_ KAVFY 106_ CGMAV 111_ VPIVI 116_ SLTLT 121_ TLLGN 126_ AIAFA 131_ TGVLY 136_ GLSAL 141_ GKKGD 146_ AISYA 151_ RIQQQ 156_ RQQAD 161_ EEKLA 166_ETLEG
1: Transmembrane protein which mediates synaptic endocytosis and fitness-based cell culling (PubMed:31341286, PubMed:37348560). In response to different stimulus strengths, controls two major modes of synaptic vesicle (SV) retrieval in hippocampal neurons; Clathrin-mediated endocytosis (CME) in response to mild stimulation and activity-dependent bulk endocytosis (ADBE) in response to strong stimulation (By similarity). In cytotoxic T-lymphoocytes (CTLs) facilitates calcium-dependent endocytosis of cytotoxic granules at the immuno synapse (By similarity). Different isoforms work as fitness fingerprints in 'loser' and 'winner' cells and thereby mediate win/lose decisions as part of the cell competition process (PubMed:31341286)
2: Functions with the other flower isoforms to produce tissue-specific fitness fingerprints that identify unfit or fit cells during cell selection processes in order to maintain tissue health (PubMed:31341286). During cell competition, if levels of this isoform in cells is higher than in the surrounding neighboring cells, the cells are recognized as 'winner' cells, and do not undergo elimination via apoptosis (PubMed:31341286)
3: Functions with the other flower isoforms to produce tissue-specific fitness fingerprints that identify unfit or fit cells during cell selection processes in order to maintain tissue health (PubMed:31341286). During cell competition, if levels of this isoform in unfit cells is higher than in the surrounding neighboring cells, the cells are recognized as 'loser' cells, and undergo elimination via apoptosis to be replaced by the surrounding healthy 'winner' cell population (PubMed:31341286)
4: Functions with the other flower isoforms to produce tissue-specific fitness fingerprints that identify unfit or fit cells during cell selection processes in order to maintain tissue health (PubMed:31341286). During cell competition, if levels of this isoform in unfit cells is higher than in the surrounding neighboring cells, the cells are recognized as 'loser' cells, and undergo elimination via apoptosis to be replaced by the surrounding healthy 'winner' cell population (PubMed:31341286)
5: Functions with the other flower isoforms to produce tissue-specific fitness fingerprints that identify unfit or fit cells during cell selection processes in order to maintain tissue health (PubMed:31341286). During cell competition, if levels of this isoform in cells is higher than in the surrounding neighboring cells, the cells are recognized as 'winner' cells, and do not undergo elimination via apoptosis (PubMed:31341286)