Nucleolar protein 12
1_MGRNK 6_ KKKRD 11_ GDDRR 16_ PRLVL 21_ SFDEE 26_ KRREY 31_ LTGFH 36_ KRKVE 41_ RKKAA 46_ IEEIK 51_ QRLKE 56_ EQRKL 61_ REERH 66_ QEYLK 71_ MLAER 76_ EEALE 81_ EADEL 86_ DRLVT 91_ AKTES 96_ VQYDH 101_ PNHTV 106_ TVTTI 111_ SDLDL 116_ SGARL 121_ LGLTP 126_ PEGGA 131_ GDRSE 136_ EEASS 141_ TEKPT 146_ KALPR 151_ KSRDP 156_ LLSQR 161_ ISSLT 166_ ASLHA 171_ HSRKK 176_ VKRKH 181_ PRRAQ 186_ DSKKP 191_ PRAPR 196_ TSKAQ 201_ RRRLT 206_GKARH
1: Multifunctional RNA binding protein that plays a role in RNA metabolism and DNA maintenance. Participates in the resolution of DNA stress and the maintenance of genome integrity by localizing to sites of DNA insults (PubMed:29069457). Also plays a role in proper nucleolar organization by limiting nucleolar size and regulating nucleolar number. Mechanistically, regulates the nucleolar levels of fibrillarin and nucleolin, two key players in pre-rRNA processing and ribosome assembly (PubMed:30988155)