DNA dC->dU-editing enzyme APOBEC-3B (A3B) (EC 3.5.4.38) (Phorbolin-1-related protein) (Phorbolin-2/3)
1_MNPQI 6_ RNPME 11_ RMYRD 16_ TFYDN 21_ FENEP 26_ ILYGR 31_ SYTWL 36_ CYEVK 41_ IKRGR 46_ SNLLW 51_ DTGVF 56_ RGQVY 61_ FKPQY 66_ HAEMC 71_ FLSWF 76_ CGNQL 81_ PAYKC 86_ FQITW 91_ FVSWT 96_ PCPDC 101_ VAKLA 106_ EFLSE 111_ HPNVT 116_ LTISA 121_ ARLYY 126_ YWERD 131_ YRRAL 136_ CRLSQ 141_ AGARV 146_ TIMDY 151_ EEFAY 156_ CWENF 161_ VYNEG 166_ QQFMP 171_ WYKFD 176_ ENYAF 181_ LHRTL 186_ KEILR 191_ YLMDP 196_ DTFTF 201_ NFNND 206_ PLVLR 211_ RRQTY 216_ LCYEV 221_ ERLDN 226_ GTWVL 231_ MDQHM 236_ GFLCN 241_ EAKNL 246_ LCGFY 251_ GRHAE 256_ LRFLD 261_ LVPSL 266_ QLDPA 271_ QIYRV 276_ TWFIS 281_ WSPCF 286_ SWGCA 291_ GEVRA 296_ FLQEN 301_ THVRL 306_ RIFAA 311_ RIYDY 316_ DPLYK 321_ EALQM 326_ LRDAG 331_ AQVSI 336_ MTYDE 341_ FEYCW 346_ DTFVY 351_ RQGCP 356_ FQPWD 361_ GLEEH 366_ SQALS 371_ GRLRA 376_ILQNQ
1: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons