Switch-associated protein 70 (SWAP-70)
1_MGSLK 6_ EELLK 11_ AIWHA 16_ FTALD 21_ QDHSG 26_ KVSKS 31_ QLKVL 36_ SHNLC 41_ TVLKV 46_ PHDPV 51_ ALEEH 56_ FRDDD 61_ EGPVS 66_ NQGYM 71_ PYLNR 76_ FILEK 81_ VQDNF 86_ DKIEF 91_ NRMCW 96_ TLCVK 101_ KNLTK 106_ NPLLI 111_ TEEDA 116_ FKIWV 121_ IFNFL 126_ SEDKY 131_ PLIIV 136_ SEEIE 141_ YLLKK 146_ LTEAM 151_ GGGWQ 156_ QEQFE 161_ HYKIN 166_ FDDSK 171_ NGLSA 176_ WELIE 181_ LIGNG 186_ QFSKG 191_ MDRQT 196_ VSMAI 201_ NEVFN 206_ ELILD 211_ VLKQG 216_ YMMKK 221_ GHRRK 226_ NWTER 231_ WFVLK 236_ PNIIS 241_ YYVSE 246_ DLKDK 251_ KGDIL 256_ LDENC 261_ CVESL 266_ PDKDG 271_ KKCLF 276_ LVKCF 281_ DKTFE 286_ ISASD 291_ KKKKQ 296_ EWIQA 301_ IHSTI 306_ HLLKL 311_ GSPPP 316_ HKEAR 321_ QRRKE 326_ LRKKQ 331_ LAEQE 336_ ELERQ 341_ MKELQ 346_ AANES 351_ KQQEL 356_ EAVRK 361_ KLEEA 366_ ASRAA 371_ EEEKK 376_ RLQTQ 381_ VELQA 386_ RFSTE 391_ LEREK 396_ LIRQQ 401_ MEEQV 406_ AQKSS 411_ ELEQY 416_ LQRVR 421_ ELEDM 426_ YLKLQ 431_ EALED 436_ ERQAR 441_ QDEET 446_ VRKLQ 451_ ARLLE 456_ EESSK 461_ RAELE 466_ KWHLE 471_ QQQAI 476_ QTTEA 481_ EKQEL 486_ ENQRV 491_ LKEQA 496_ LQEAM 501_ EQLEQ 506_ LELER 511_ KQALE 516_ QYEEV 521_ KKKLE 526_ MATNK 531_ TKSWK 536_ DKVAH 541_ HEGLI 546_ RLIEP 551_ GSKNP 556_ HLITN 561_ WGPAA 566_ FTEAE 571_ LEERE 576_KNWKE
1: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity)