Transcription factor COE1 (O/E-1) (OE-1) (Early B-cell factor)
1_MFGIQ 6_ ESIQR 11_ SGSSM 16_ KEEPL 21_ GSGMN 26_ AVRTW 31_ MQGAG 36_ VLDAN 41_ TAAQS 46_ GVGLA 51_ RAHFE 56_ KQPPS 61_ NLRKS 66_ NFFHF 71_ VLALY 76_ DRQGQ 81_ PVEIE 86_ RTAFV 91_ GFVEK 96_ EKEAN 101_ SEKTN 106_ NGIHY 111_ RLQLL 116_ YSNGI 121_ RTEQD 126_ FYVRL 131_ IDSMT 136_ KQAIV 141_ YEGQD 146_ KNPEM 151_ CRVLL 156_ THEIM 161_ CSRCC 166_ DKKSC 171_ GNRNE 176_ TPSDP 181_ VIIDR 186_ FFLKF 191_ FLKCN 196_ QNCLK 201_ NAGNP 206_ RDMRR 211_ FQVVV 216_ STTVN 221_ VDGHV 226_ LAVSD 231_ NMFVH 236_ NNSKH 241_ GRRAR 246_ RLDPS 251_ EGTPS 256_ YLEHA 261_ TPCIK 266_ AISPS 271_ EGWTT 276_ GGATV 281_ IIIGD 286_ NFFDG 291_ LQVIF 296_ GTMLV 301_ WSELI 306_ TPHAI 311_ RVQTP 316_ PRHIP 321_ GVVEV 326_ TLSYK 331_ SKQFC 336_ KGTPG 341_ RFIYT 346_ ALNEP 351_ TIDYG 356_ FQRLQ 361_ KVIPR 366_ HPGDP 371_ ERLPK 376_ EVILK 381_ RAADL 386_ VEALY 391_ GMPHN 396_ NQEII 401_ LKRAA 406_ DIAEA 411_ LYSVP 416_ RNHNQ 421_ LPALA 426_ NTSVH 431_ AGMMG 436_ VNSFS 441_ GQLAV 446_ NVSEA 451_ SQATN 456_ QGFTR 461_ NSSSV 466_ SPHGY 471_ VPSTT 476_ PQQTN 481_ YNSVT 486_ TSMNG 491_ YGSAA 496_ MSNLG 501_ GSPTF 506_ LNGSA 511_ ANSPY 516_ AIVPS 521_ SPTMA 526_ SSTSL 531_ PSNCS 536_ SSSGI 541_ FSFSP 546_ ANMVS 551_ AVKQK 556_ SAFAP 561_ VVRPQ 566_ TSPPP 571_ TCTST 576_ NGNSL 581_ QAISG 586_MIVPP
1: Key pioneer transcription factor of B-cell specification and commitment (PubMed:27807034). Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates. For instance, positively regulates many B-cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage. In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold (By similarity)
2: (Microbial infection) Acts as a chromatin anchor for Epstein-Barr virus EBNA2 to mediate the assembly of EBNA2 chromatin complexes in B-cells (PubMed:28968461). In addition, binds to the viral LMP1 proximal promoter and promotes its expression during latency (PubMed:26819314)