Kelch-like protein 3
1_MEGES 6_ VKLSS 11_ QTLIQ 16_ AGDDE 21_ KNQRT 26_ ITVNP 31_ AHMGK 36_ AFKVM 41_ NELRS 46_ KQLLC 51_ DVMIV 56_ AEDVE 61_ IEAHR 66_ VVLAA 71_ CSPYF 76_ CAMFT 81_ GDMSE 86_ SKAKK 91_ IEIKD 96_ VDGQT 101_ LSKLI 106_ DYIYT 111_ AEIEV 116_ TEENV 121_ QVLLP 126_ AASLL 131_ QLMDV 136_ RQNCC 141_ DFLQS 146_ QLHPT 151_ NCLGI 156_ RAFAD 161_ VHTCT 166_ DLLQQ 171_ ANAYA 176_ EQHFP 181_ EVMLG 186_ EEFLS 191_ LSLDQ 196_ VCSLI 201_ SSDKL 206_ TVSSE 211_ EKVFE 216_ AVISW 221_ INYEK 226_ ETRLE 231_ HMAKL 236_ MEHVR 241_ LPLLP 246_ RDYLV 251_ QTVEE 256_ EALIK 261_ NNNTC 266_ KDFLI 271_ EAMKY 276_ HLLPL 281_ DQRLL 286_ IKNPR 291_ TKPRT 296_ PVSLP 301_ KVMIV 306_ VGGQA 311_ PKAIR 316_ SVECY 321_ DFEED 326_ RWDQI 331_ AELPS 336_ RRCRA 341_ GVVFM 346_ AGHVY 351_ AVGGF 356_ NGSLR 361_ VRTVD 366_ VYDGV 371_ KDQWT 376_ SIASM 381_ QERRS 386_ TLGAA 391_ VLNDL 396_ LYAVG 401_ GFDGS 406_ TGLAS 411_ VEAYS 416_ YKTNE 421_ WFFVA 426_ PMNTR 431_ RSSVG 436_ VGVVE 441_ GKLYA 446_ VGGYD 451_ GASRQ 456_ CLSTV 461_ EQYNP 466_ ATNEW 471_ IYVAD 476_ MSTRR 481_ SGAGV 486_ GVLSG 491_ QLYAT 496_ GGHDG 501_ PLVRK 506_ SVEVY 511_ DPGTN 516_ TWKQV 521_ ADMNM 526_ CRRNA 531_ GVCAV 536_ NGLLY 541_ VVGGD 546_ DGSCN 551_ LASVE 556_ YYNPV 561_ TDKWT 566_ LLPTN 571_ MSTGR 576_ SYAGV 581_AVIHK
1: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of ion transport in the distal nephron (PubMed:14528312, PubMed:22406640, PubMed:23387299, PubMed:23453970, PubMed:23576762, PubMed:23665031, PubMed:25313067, PubMed:35093948). The BCR(KLHL3) complex acts by mediating ubiquitination and degradation of WNK1 and WNK4, two activators of Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney, thereby regulating NaCl reabsorption (PubMed:23387299, PubMed:23453970, PubMed:23576762, PubMed:23665031, PubMed:25313067, PubMed:35093948). The BCR(KLHL3) complex also mediates ubiquitination and degradation of WNK3 (PubMed:35179207). The BCR(KLHL3) complex also mediates ubiquitination of CLDN8, a tight-junction protein required for paracellular chloride transport in the kidney, leading to its degradation (By similarity)