SUN domain-containing protein 2 (Protein unc-84 homolog B) (Rab5-interacting protein) (Rab5IP) (Sad1/unc-84 protein-like 2)
1_MSRRS 6_ QRLTR 11_ YSQGD 16_ DDGSS 21_ SSGGS 26_ SVAGS 31_ QSTLF 36_ KDSPL 41_ RTLKR 46_ KSSNM 51_ KRLSP 56_ APQLG 61_ PSSDA 66_ HTSYY 71_ SESLV 76_ HESWF 81_ PPRSS 86_ LEELH 91_ GDANW 96_ GEDLR 101_ VRRRR 106_ GTGGS 111_ ESSRA 116_ SGLVG 121_ RKATE 126_ DFLGS 131_ SSGYS 136_ SEDDY 141_ VGYSD 146_ VDQQS 151_ SSSRL 156_ RSAVS 161_ RAGSL 166_ LWMVA 171_ TSPGR 176_ LFRLL 181_ YWWAG 186_ TTWYR 191_ LTTAA 196_ SLLDV 201_ FVLTR 206_ RFSSL 211_ KTFLW 216_ FLLPL 221_ LLLTC 226_ LTYGA 231_ WYFYP 236_ YGLQT 241_ FHPAL 246_ VSWWA 251_ AKDSR 256_ RPDEG 261_ WEARD 266_ SSPHF 271_ QAEQR 276_ VMSRV 281_ HSLER 286_ RLEAL 291_ AAEFS 296_ SNWQK 301_ EAMRL 306_ ERLEL 311_ RQGAP 316_ GQGGG 321_ GGLSH 326_ EDTLA 331_ LLEGL 336_ VSRRE 341_ AALKE 346_ DFRRE 351_ TAARI 356_ QEELS 361_ ALRAE 366_ HQQDS 371_ EDLFK 376_ KIVRA 381_ SQESE 386_ ARIQQ 391_ LKSEW 396_ QSMTQ 401_ ESFQE 406_ SSVKE 411_ LRRLE 416_ DQLAG 421_ LQQEL 426_ AALAL 431_ KQSSV 436_ AEEVG 441_ LLPQQ 446_ IQAVR 451_ DDVES 456_ QFPAW 461_ ISQFL 466_ ARGGG 471_ GRVGL 476_ LQREE 481_ MQAQL 486_ RELES 491_ KILTH 496_ VAEMQ 501_ GKSAR 506_ EAAAS 511_ LSLTL 516_ QKEGV 521_ IGVTE 526_ EQVHH 531_ IVKQA 536_ LQRYS 541_ EDRIG 546_ LADYA 551_ LESGG 556_ ASVIS 561_ TRCSE 566_ TYETK 571_ TALLS 576_ LFGIP 581_ LWYHS 586_ QSPRV 591_ ILQPD 596_ VHPGN 601_ CWAFQ 606_ GPQGF 611_ AVVRL 616_ SARIR 621_ PTAVT 626_ LEHVP 631_ KALSP 636_ NSTIS 641_ SAPKD 646_ FAIFG 651_ FDEDL 656_ QQEGT 661_ LLGKF 666_ TYDQD 671_ GEPIQ 676_ TFHFQ 681_ APTMA 686_ TYQVV 691_ ELRIL 696_ TNWGH 701_ PEYTC 706_ IYRFR 711_VHGEP
1: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for RAB5-GDP and participate in the activation of RAB5