AF4/FMR2 family member 4 (ALL1-fused gene from chromosome 5q31 protein) (Protein AF-5q31) (Major CDK9 elongation factor-associated protein)
1_MNRED 6_ RNVLR 11_ MKERE 16_ RRNQE 21_ IQQGE 26_ DAFPP 31_ SSPLF 36_ AEPYK 41_ VTSKE 46_ DKLSS 51_ RIQSM 56_ LGNYD 61_ EMKDF 66_ IGDRS 71_ IPKLV 76_ AIPKP 81_ TVPPS 86_ ADEKS 91_ NPNFF 96_ EQRHG 101_ GSHQS 106_ SKWTP 111_ VGPAP 116_ STSQS 121_ QKRSS 126_ GLQSG 131_ HSSQR 136_ TSAGS 141_ SSGTN 146_ SSGQR 151_ HDRES 156_ YNNSG 161_ SSSRK 166_ KGQHG 171_ SEHSK 176_ SRSSS 181_ PGKPQ 186_ AVSSL 191_ NSSHS 196_ RSHGN 201_ DHHSK 206_ EHQRS 211_ KSPRD 216_ PDANW 221_ DSPSR 226_ VPFSS 231_ GQHST 236_ QSFPP 241_ SLMSK 246_ SNSML 251_ QKPTA 256_ YVRPM 261_ DGQES 266_ MEPKL 271_ SSEHY 276_ SSQSH 281_ GNSMT 286_ ELKPS 291_ SKAHL 296_ TKLKI 301_ PSQPL 306_ DASAS 311_ GDVSC 316_ VDEIL 321_ KEMTH 326_ SWPPP 331_ LTAIH 336_ TPCKT 341_ EPSKF 346_ PFPTK 351_ ESQQS 356_ NFGTG 361_ EQKRY 366_ NPSKT 371_ SNGHQ 376_ SKSML 381_ KDDLK 386_ LSSSE 391_ DSDGE 396_ QDCDK 401_ TMPRS 406_ TPGSN 411_ SEPSH 416_ HNSEG 421_ ADNSR 426_ DDSSS 431_ HSGSE 436_ SSSGS 441_ DSESE 446_ SSSSD 451_ SEANE 456_ PSQSA 461_ SPEPE 466_ PPPTN 471_ KWQLD 476_ NWLNK 481_ VNPHK 486_ VSPAS 491_ SVDSN 496_ IPSSQ 501_ GYKKE 506_ GREQG 511_ TGNSY 516_ TDTSG 521_ PKETS 526_ SATPG 531_ RDSKT 536_ IQKGS 541_ ESGRG 546_ RQKSP 551_ AQSDS 556_ TTQRR 561_ TVGKK 566_ QPKKA 571_ EKAAA 576_ EEPRG 581_ GLKIE 586_ SETPV 591_ DLASS 596_ MPSSR 601_ HKAAT 606_ KGSRK 611_ PNIKK 616_ ESKSS 621_ PRPTA 626_ EKKKY 631_ KSTSK 636_ SSQKS 641_ REIIE 646_ TDTSS 651_ SDSDE 656_ SESLP 661_ PSSQT 666_ PKYPE 671_ SNRTP 676_ VKPSS 681_ VEEED 686_ SFFRQ 691_ RMFSP 696_ MEEKE 701_ LLSPL 706_ SEPDD 711_ RYPLI 716_ VKIDL 721_ NLLTR 726_ IPGKP 731_ YKETE 736_ PPKGE 741_ KKNVP 746_ EKHTR 751_ EAQKQ 756_ ASEKV 761_ SNKGK 766_ RKHKN 771_ EDDNR 776_ ASESK 781_ KPKTE 786_ DKNSA 791_ GHKPS 796_ SNRES 801_ SKQSA 806_ AKEKD 811_ LLPSP 816_ AGPVP 821_ SKDPK 826_ TEHGS 831_ RKRTI 836_ SQSSS 841_ LKSSS 846_ NSNKE 851_ TSGSS 856_ KNSSS 861_ TSKQK 866_ KTEGK 871_ TSSSS 876_ KEVKE 881_ KAPSS 886_ SSNCP 891_ PSAPT 896_ LDSSK 901_ PRRTK 906_ LVFDD 911_ RNYSA 916_ DHYLQ 921_ EAKKL 926_ KHNAD 931_ ALSDR 936_ FEKAV 941_ YYLDA 946_ VVSFI 951_ ECGNA 956_ LEKNA 961_ QESKS 966_ PFPMY 971_ SETVD 976_ LIKYT 981_ MKLKN 986_ YLAPD 991_ ATAAD 996_ KRLTV 1001_ LCLRC 1006_ ESLLY 1011_ LRLFK 1016_ LKKEN 1021_ ALKYS 1026_ KTLTE 1031_ HLKNS 1036_ YNNSQ 1041_ APSPG 1046_ LGSKA 1051_ VGMPS 1056_ PVSPK 1061_ LSPGN 1066_ SGNYS 1071_ SGASS 1076_ ASASG 1081_ SSVTI 1086_ PQKIH 1091_ QMAAS 1096_ YVQVT 1101_ SNFLY 1106_ ATEIW 1111_ DQAEQ 1116_ LSKEQ 1121_ KEFFA 1126_ ELDKV 1131_ MGPLI 1136_ FNASI 1141_ MTDLV 1146_ RYTRQ 1151_ GLHWL 1156_RQDAK
1: Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression