Signal recognition particle subunit SRP68 (SRP68) (Signal recognition particle 68 kDa protein)
1_MAAEK 6_ QVPGG 11_ GGGGG 16_ SGGGG 21_ GSGGG 26_ GSGGG 31_ RGAGG 36_ EENKE 41_ NERPS 46_ AGSKA 51_ NKEFG 56_ DSLSL 61_ EILQI 66_ IKESQ 71_ QQHGL 76_ RHGDF 81_ QRYRG 86_ YCSRR 91_ QRRLR 96_ KTLNF 101_ KMGNR 106_ HKFTG 111_ KKVTE 116_ ELLTD 121_ NRYLL 126_ LVLMD 131_ AERAW 136_ SYAMQ 141_ LKQEA 146_ NTEPR 151_ KRFHL 156_ LSRLR 161_ KAVKH 166_ AEELE 171_ RLCES 176_ NRVDA 181_ KTKLE 186_ AQAYT 191_ AYLSG 196_ MLRFE 201_ HQEWK 206_ AAIEA 211_ FNKCK 216_ TIYEK 221_ LASAF 226_ TEEQA 231_ VLYNQ 236_ RVEEI 241_ SPNIR 246_ YCAYN 251_ IGDQS 256_ AINEL 261_ MQMRL 266_ RSGGT 271_ EGLLA 276_ EKLEA 281_ LITQT 286_ RAKQA 291_ ATMSE 296_ VEWRG 301_ RTVPV 306_ KIDKV 311_ RIFLL 316_ GLADN 321_ EAAIV 326_ QAESE 331_ ETKER 336_ LFESM 341_ LSECR 346_ DAIQV 351_ VREEL 356_ KPDQK 361_ QRDYI 366_ LEGEP 371_ GKVSN 376_ LQYLH 381_ SYLTY 386_ IKLST 391_ AIKRN 396_ ENMAK 401_ GLQRA 406_ LLQQQ 411_ PEDDS 416_ KRSPR 421_ PQDLI 426_ RLYDI 431_ ILQNL 436_ VELLQ 441_ LPGLE 446_ EDKAF 451_ QKEIG 456_ LKTLV 461_ FKAYR 466_ CFFIA 471_ QSYVL 476_ VKKWS 481_ EALVL 486_ YDRVL 491_ KYANE 496_ VNSDA 501_ GAFKN 506_ SLKDL 511_ PDVQE 516_ LITQV 521_ RSEKC 526_ SLQAA 531_ AILDA 536_ NDAHQ 541_ TETSS 546_ SQVKD 551_ NKPLV 556_ ERFET 561_ FCLDP 566_ SLVTK 571_ QANLV 576_ HFPPG 581_ FQPIP 586_ CKPLF 591_ FDLAL 596_ NHVAF 601_ PPLED 606_ KLEQK 611_ TKSGL 616_ TGYIK 621_GIFGF
1: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (PubMed:34020957). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (PubMed:34020957). Binds the signal recognition particle RNA (7SL RNA), SRP72 binds to this complex subsequently (PubMed:16672232, PubMed:27899666). The SRP complex possibly participates in the elongation arrest function (By similarity)