E3 ubiquitin-protein ligase makorin-1 (EC 2.3.2.27) (RING finger protein 61) (RING-type E3 ubiquitin transferase makorin-1)
1_MAEAA 6_ TPGTT 11_ ATTSG 16_ AGAAA 21_ ATAAA 26_ ASPTP 31_ IPTVT 36_ APSLG 41_ AGGGG 46_ GGSDG 51_ SGGGW 56_ TKQVT 61_ CRYFM 66_ HGVCK 71_ EGDNC 76_ RYSHD 81_ LSDSP 86_ YSVVC 91_ KYFQR 96_ GYCIY 101_ GDRCR 106_ YEHSK 111_ PLKQE 116_ EATAT 121_ ELTTK 126_ SSLAA 131_ SSSLS 136_ SIVGP 141_ LVEMN 146_ TGEAE 151_ SRNSN 156_ FATVG 161_ AGSED 166_ WVNAI 171_ EFVPG 176_ QPYCG 181_ RTAPS 186_ CTEAP 191_ LQGSV 196_ TKEES 201_ EKEQT 206_ AVETK 211_ KQLCP 216_ YAAVG 221_ ECRYG 226_ ENCVY 231_ LHGDS 236_ CDMCG 241_ LQVLH 246_ PMDAA 251_ QRSQH 256_ IKSCI 261_ EAHEK 266_ DMELS 271_ FAVQR 276_ SKDMV 281_ CGICM 286_ EVVYE 291_ KANPS 296_ ERRFG 301_ ILSNC 306_ NHTYC 311_ LKCIR 316_ KWRSA 321_ KQFES 326_ KIIKS 331_ CPECR 336_ ITSNF 341_ VIPSE 346_ YWVEE 351_ KEEKQ 356_ KLILK 361_ YKEAM 366_ SNKAC 371_ RYFDE 376_ GRGSC 381_ PFGGN 386_ CFYKH 391_ AYPDG 396_ RREEP 401_ QRQKV 406_ GTSSR 411_ YRAQR 416_ RNHFW 421_ ELIEE 426_ RENSN 431_ PFDND 436_ EEEVV 441_ TFELG 446_ EMLLM 451_ LLAAG 456_ GDDEL 461_ TDSED 466_ EWDLF 471_ HDELE 476_DFYDL
1: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription