NPC1-like intracellular cholesterol transporter 1 (Niemann-Pick C1-like protein 1)
1_MAEAG 6_ LRGWL 11_ LWALL 16_ LRLAQ 21_ SEPYT 26_ TIHQP 31_ GYCAF 36_ YDECG 41_ KNPEL 46_ SGSLM 51_ TLSNV 56_ SCLSN 61_ TPARK 66_ ITGDH 71_ LILLQ 76_ KICPR 81_ LYTGP 86_ NTQAC 91_ CSAKQ 96_ LVSLE 101_ ASLSI 106_ TKALL 111_ TRCPA 116_ CSDNF 121_ VNLHC 126_ HNTCS 131_ PNQSL 136_ FINVT 141_ RVAQL 146_ GAGQL 151_ PAVVA 156_ YEAFY 161_ QHSFA 166_ EQSYD 171_ SCSRV 176_ RVPAA 181_ ATLAV 186_ GTMCG 191_ VYGSA 196_ LCNAQ 201_ RWLNF 206_ QGDTG 211_ NGLAP 216_ LDITF 221_ HLLEP 226_ GQAVG 231_ SGIQP 236_ LNEGV 241_ ARCNE 246_ SQGDD 251_ VATCS 256_ CQDCA 261_ ASCPA 266_ IARPQ 271_ ALDST 276_ FYLGQ 281_ MPGSL 286_ VLIII 291_ LCSVF 296_ AVVTI 301_ LLVGF 306_ RVAPA 311_ RDKSK 316_ MVDPK 321_ KGTSL 326_ SDKLS 331_ FSTHT 336_ LLGQF 341_ FQGWG 346_ TWVAS 351_ WPLTI 356_ LVLSV 361_ IPVVA 366_ LAAGL 371_ VFTEL 376_ TTDPV 381_ ELWSA 386_ PNSQA 391_ RSEKA 396_ FHDQH 401_ FGPFF 406_ RTNQV 411_ ILTAP 416_ NRSSY 421_ RYDSL 426_ LLGPK 431_ NFSGI 436_ LDLDL 441_ LLELL 446_ ELQER 451_ LRHLQ 456_ VWSPE 461_ AQRNI 466_ SLQDI 471_ CYAPL 476_ NPDNT 481_ SLYDC 486_ CINSL 491_ LQYFQ 496_ NNRTL 501_ LLLTA 506_ NQTLM 511_ GQTSQ 516_ VDWKD 521_ HFLYC 526_ ANAPL 531_ TFKDG 536_ TALAL 541_ SCMAD 546_ YGAPV 551_ FPFLA 556_ IGGYK 561_ GKDYS 566_ EAEAL 571_ IMTFS 576_ LNNYP 581_ AGDPR 586_ LAQAK 591_ LWEEA 596_ FLEEM 601_ RAFQR 606_ RMAGM 611_ FQVTF 616_ MAERS 621_ LEDEI 626_ NRTTA 631_ EDLPI 636_ FATSY 641_ IVIFL 646_ YISLA 651_ LGSYS 656_ SWSRV 661_ MVDSK 666_ ATLGL 671_ GGVAV 676_ VLGAV 681_ MAAMG 686_ FFSYL 691_ GIRSS 696_ LVILQ 701_ VVPFL 706_ VLSVG 711_ ADNIF 716_ IFVLE 721_ YQRLP 726_ RRPGE 731_ PREVH 736_ IGRAL 741_ GRVAP 746_ SMLLC 751_ SLSEA 756_ ICFFL 761_ GALTP 766_ MPAVR 771_ TFALT 776_ SGLAV 781_ ILDFL 786_ LQMSA 791_ FVALL 796_ SLDSK 801_ RQEAS 806_ RLDVC 811_ CCVKP 816_ QELPP 821_ PGQGE 826_ GLLLG 831_ FFQKA 836_ YAPFL 841_ LHWIT 846_ RGVVL 851_ LLFLA 856_ LFGVS 861_ LYSMC 866_ HISVG 871_ LDQEL 876_ ALPKD 881_ SYLLD 886_ YFLFL 891_ NRYFE 896_ VGAPV 901_ YFVTT 906_ LGYNF 911_ SSEAG 916_ MNAIC 921_ SSAGC 926_ NNFSF 931_ TQKIQ 936_ YATEF 941_ PEQSY 946_ LAIPA 951_ SSWVD 956_ DFIDW 961_ LTPSS 966_ CCRLY 971_ ISGPN 976_ KDKFC 981_ PSTVN 986_ SLNCL 991_ KNCMS 996_ ITMGS 1001_ VRPSV 1006_ EQFHK 1011_ YLPWF 1016_ LNDRP 1021_ NIKCP 1026_ KGGLA 1031_ AYSTS 1036_ VNLTS 1041_ DGQVL 1046_ DTVAI 1051_ LSPRL 1056_ EYSGT 1061_ ISAHC 1066_ NLYLL 1071_ DSTSR 1076_ FMAYH 1081_ KPLKN 1086_ SQDYT 1091_ EALRA 1096_ ARELA 1101_ ANITA 1106_ DLRKV 1111_ PGTDP 1116_ AFEVF 1121_ PYTIT 1126_ NVFYE 1131_ QYLTI 1136_ LPEGL 1141_ FMLSL 1146_ CLVPT 1151_ FAVSC 1156_ LLLGL 1161_ DLRSG 1166_ LLNLL 1171_ SIVMI 1176_ LVDTV 1181_ GFMAL 1186_ WGISY 1191_ NAVSL 1196_ INLVS 1201_ AVGMS 1206_ VEFVS 1211_ HITRS 1216_ FAIST 1221_ KPTWL 1226_ ERAKE 1231_ ATISM 1236_ GSAVF 1241_ AGVAM 1246_ TNLPG 1251_ ILVLG 1256_ LAKAQ 1261_ LIQIF 1266_ FFRLN 1271_ LLITL 1276_ LGLLH 1281_ GLVFL 1286_ PVILS 1291_ YVGPD 1296_ VNPAL 1301_ ALEQK 1306_ RAEEA 1311_ VAAVM 1316_ VASCP 1321_ NHPSR 1326_ VSTAD 1331_ NIYVN 1336_ HSFEG 1341_ SIKGA 1346_ GAISN 1351_FLPNN
1: Plays a major role in cholesterol homeostasis (PubMed:22095670). Critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte (PubMed:22095670). Involved in plant sterol absorption, it transports sitosterol, although at lower rates than cholesterol (By similarity). Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption and is approved for the treatment of hypercholesterolemia (PubMed:15928087). May have a function in the transport of multiple lipids and their homeostasis, thereby influencing lipid metabolism regulation (PubMed:15671032). May be involved in caveolin trafficking from the plasma membrane (By similarity). In addition, acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation (PubMed:22095670)