Interleukin-19 (IL-19) (Melanoma differentiation-associated protein-like protein) (NG.1)
1_MKLQC 6_ VSLWL 11_ LGTIL 16_ ILCSV 21_ DNHGL 26_ RRCLI 31_ STDMH 36_ HIEES 41_ FQEIK 46_ RAIQA 51_ KDTFP 56_ NVTIL 61_ STLET 66_ LQIIK 71_ PLDVC 76_ CVTKN 81_ LLAFY 86_ VDRVF 91_ KDHQE 96_ PNPKI 101_ LRKIS 106_ SIANS 111_ FLYMQ 116_ KTLRQ 121_ CQEQR 126_ QCHCR 131_ QEATN 136_ ATRVI 141_ HDNYD 146_ QLEVH 151_ AAAIK 156_ SLGEL 161_ DVFLA 166_ WINKN 171_HEVMF
1: Cytokine that functions as an anti-inflammatory and proangiogenic factor (PubMed:34932373). Polarizes adaptive immunity to an anti-inflammatory phenotype through induction of T-helper 2 responses by both down-regulation of IFN-gamma and up-regulation of IL4 and IL13 (PubMed:16365913). Produced by osteocytes, stimulates granulopoiesis and neutrophil formation (By similarity). Exerts its biological effect through a receptor complex consisting of a heterodimer of IL20RA and IL20RB (PubMed:12351624). In turn, activates the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, and importantly, STAT3 (PubMed:11564763)