Cysteine and histidine-rich domain-containing protein 1 (CHORD domain-containing protein 1) (CHORD-containing protein 1) (CHP-1) (Protein morgana)
1_MALLC 6_ YNRGC 11_ GQRFD 16_ PETNS 21_ DDACT 26_ YHPGV 31_ PVFHD 36_ ALKGW 41_ SCCKR 46_ RTTDF 51_ SDFLS 56_ IVGCT 61_ KGRHN 66_ SEKPP 71_ EPVKP 76_ EVKTT 81_ EKKEL 86_ CELKP 91_ KFQEH 96_ IIQAP 101_ KPVEA 106_ IKRPS 111_ PDEPM 116_ TNLEL 121_ KISAS 126_ LKQAL 131_ DKLKL 136_ SSGNE 141_ ENKKE 146_ EDNDE 151_ IKIGT 156_ SCKNG 161_ GCSKT 166_ YQGLE 171_ SLEEV 176_ CVYHS 181_ GVPIF 186_ HEGMK 191_ YWSCC 196_ RRKTS 201_ DFNTF 206_ LAQEG 211_ CTKGK 216_ HMWTK 221_ KDAGK 226_ KVVPC 231_ RHDWH 236_ QTGGE 241_ VTISV 246_ YAKNS 251_ LPELS 256_ RVEAN 261_ STLLN 266_ VHIVF 271_ EGEKE 276_ FDQNV 281_ KLWGV 286_ IDVKR 291_ SYVTM 296_ TATKI 301_ EITMR 306_ KAEPM 311_ QWASL 316_ ELPAA 321_ KKQEK 326_QKDAT
1: Regulates centrosome duplication, probably by inhibiting the kinase activity of ROCK2 (PubMed:20230755). Proposed to act as co-chaperone for HSP90 (PubMed:20230755). May play a role in the regulation of NOD1 via a HSP90 chaperone complex (PubMed:20230755). In vitro, has intrinsic chaperone activity (PubMed:20230755). This function may be achieved by inhibiting association of ROCK2 with NPM1 (PubMed:20230755). Plays a role in ensuring the localization of the tyrosine kinase receptor EGFR to the plasma membrane, and thus ensures the subsequent regulation of EGFR activity and EGF-induced actin cytoskeleton remodeling (PubMed:32053105). Involved in stress response (PubMed:20230755). Prevents tumorigenesis (PubMed:20230755)