Cell death activator CIDE-B (Cell death-inducing DFFA-like effector B)
1_MEYLS 6_ ALNPS 11_ DLLRS 16_ VSNIS 21_ SEFGR 26_ RVWTS 31_ APPPQ 36_ RPFRV 41_ CDHKR 46_ TIRKG 51_ LTAAT 56_ RQELL 61_ AKALE 66_ TLLLN 71_ GVLTL 76_ VLEED 81_ GTAVD 86_ SEDFF 91_ QLLED 96_ DTCLM 101_ VLQSG 106_ QSWSP 111_ TRSGV 116_ LSYGL 121_ GRERP 126_ KHSKD 131_ IARFT 136_ FDVYK 141_ QNPRD 146_ LFGSL 151_ NVKAT 156_ FYGLY 161_ SMSCD 166_ FQGLG 171_ PKKVL 176_ RELLR 181_ WTSTL 186_ LQGLG 191_ HMLLG 196_ ISSTL 201_ RHAVE 206_ GAEQW 211_QQKGR
1: Lipid transferase specifically expressed in hepatocytes, which promotes unilocular lipid droplet formation by mediating lipid droplet fusion (PubMed:35939579). Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage (PubMed:35939579). Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by promoting directional net neutral lipid transfer from the smaller to larger lipid droplets (By similarity). The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair (By similarity). Promotes lipid exchange and lipid droplet fusion in both small and large lipid droplet-containing hepatocytes (By similarity). In addition to its role in lipid droplet fusion, also involved in cytoplasmic vesicle biogenesis and transport (By similarity). Required for very-low-density lipoprotein (VLDL) lipidation and maturation (By similarity). Probably involved in the biogenesis of VLDL transport vesicles by forming a COPII vesicle coat and facilitating the formation of endoplasmic reticulum-derived large vesicles (By similarity). Also involved in sterol-regulated export of the SCAP-SREBP complex, composed of SCAP, SREBF1/SREBP1 and SREBF2/SREBP2, by promoting loading of SCAP-SREBP into COPII vesicles (By similarity). May also activate apoptosis (PubMed:10619428)
2: (Microbial infection) Involved in Hepatatis C virus (HCV) assembly and required for HCV entry into hepatocytes