Ubiquilin-2 (Chap1) (DSK2 homolog) (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC-2) (Ubiquitin-like product Chap1/Dsk2)
1_MAENG 6_ ESSGP 11_ PRPSR 16_ GPAAA 21_ QGSAA 26_ APAEP 31_ KIIKV 36_ TVKTP 41_ KEKEE 46_ FAVPE 51_ NSSVQ 56_ QFKEA 61_ ISKRF 66_ KSQTD 71_ QLVLI 76_ FAGKI 81_ LKDQD 86_ TLIQH 91_ GIHDG 96_ LTVHL 101_ VIKSQ 106_ NRPQG 111_ QSTQP 116_ SNAAG 121_ TNTTS 126_ ASTPR 131_ SNSTP 136_ ISTNS 141_ NPFGL 146_ GSLGG 151_ LAGLS 156_ SLGLS 161_ STNFS 166_ ELQSQ 171_ MQQQL 176_ MASPE 181_ MMIQI 186_ MENPF 191_ VQSML 196_ SNPDL 201_ MRQLI 206_ MANPQ 211_ MQQLI 216_ QRNPE 221_ ISHLL 226_ NNPDI 231_ MRQTL 236_ EIARN 241_ PAMMQ 246_ EMMRN 251_ QDLAL 256_ SNLES 261_ IPGGY 266_ NALRR 271_ MYTDI 276_ QEPML 281_ NAAQE 286_ QFGGN 291_ PFASV 296_ GSSSS 301_ SGEGT 306_ QPSRT 311_ ENRDP 316_ LPNPW 321_ APPPA 326_ TQSSA 331_ TTSTT 336_ TSTGS 341_ GSGNS 346_ SSNAT 351_ GNTVA 356_ AANYV 361_ ASIFS 366_ TPGMQ 371_ SLLQQ 376_ ITENP 381_ QLIQN 386_ MLSAP 391_ YMRSM 396_ MQSLS 401_ QNPDL 406_ AAQMM 411_ LNSPL 416_ FTANP 421_ QLQEQ 426_ MRPQL 431_ PAFLQ 436_ QMQNP 441_ DTLSA 446_ MSNPR 451_ AMQAL 456_ MQIQQ 461_ GLQTL 466_ ATEAP 471_ GLIPS 476_ FTPGV 481_ GVGVL 486_ GTAIG 491_ PVGPV 496_ TPIGP 501_ IGPIV 506_ PFTPI 511_ GPIGP 516_ IGPTG 521_ PAAPP 526_ GSTGS 531_ GGPTG 536_ PTVSS 541_ AAPSE 546_ TTSPT 551_ SESGP 556_ NQQFI 561_ QQMVQ 566_ ALAGA 571_ NAPQL 576_ PNPEV 581_ RFQQQ 586_ LEQLN 591_ AMGFL 596_ NREAN 601_ LQALI 606_ ATGGD 611_ INAAI 616_ERLLG
1: Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:10983987). Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:18307982, PubMed:24215460). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957). Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs) (PubMed:18199683)