Metalloreductase STEAP1 (EC 1.16.1.-) (Six-transmembrane epithelial antigen of prostate 1)
1_MESRK 6_ DITNQ 11_ EELWK 16_ MKPRR 21_ NLEED 26_ DYLHK 31_ DTGET 36_ SMLKR 41_ PVLLH 46_ LHQTA 51_ HADEF 56_ DCPSE 61_ LQHTQ 66_ ELFPQ 71_ WHLPI 76_ KIAAI 81_ IASLT 86_ FLYTL 91_ LREVI 96_ HPLAT 101_ SHQQY 106_ FYKIP 111_ ILVIN 116_ KVLPM 121_ VSITL 126_ LALVY 131_ LPGVI 136_ AAIVQ 141_ LHNGT 146_ KYKKF 151_ PHWLD 156_ KWMLT 161_ RKQFG 166_ LLSFF 171_ FAVLH 176_ AIYSL 181_ SYPMR 186_ RSYRY 191_ KLLNW 196_ AYQQV 201_ QQNKE 206_ DAWIE 211_ HDVWR 216_ MEIYV 221_ SLGIV 226_ GLAIL 231_ ALLAV 236_ TSIPS 241_ VSDSL 246_ TWREF 251_ HYIQS 256_ KLGIV 261_ SLLLG 266_ TIHAL 271_ IFAWN 276_ KWIDI 281_ KQFVW 286_ YTPPT 291_ FMIAV 296_ FLPIV 301_ VLIFK 306_ SILFL 311_ PCLRK 316_ KILKI 321_ RHGWE 326_ DVTKI 331_NKTEI
1: Does not function as a metalloreductase due to the absence of binding sites for the electron-donating substrate NADPH. Promotes Fe(3+) reduction when fused to the NADPH-binding domain of STEAP4