Putative N-acetyltransferase 8B (EC 2.3.1.-) (Acetyltransferase 1) (ATase1) (Camello-like protein 2)
1_MAPYH 6_ IRKYQ 11_ ESDRK 16_ SVVGL 21_ LSGGM 26_ AEHAP 31_ ATFRR 36_ LLKLP 41_ RTLIL 46_ LLGGA 51_ LALLL 56_ VSGSW 61_ ILALV 66_ FSLSL 71_ LPALW 76_ FLAKK 81_ PWTRY 86_ VDIAL 91_ RTDMS 96_ DITKS 101_ YLSEC 106_ GSCFW 111_ VAESE 116_ EKVVG 121_ TVGAL 126_ PVDDP 131_ TLREK 136_ RLQLF 141_ HLSVD 146_ NEHRG 151_ QGIAK 156_ ALVRT 161_ VLQFA 166_ RDQGY 171_ SEVVL 176_ DTSNI 181_ QLSAM 186_ GLYQS 191_ LGFKK 196_ TGQSF 201_ FHVWA 206_ RLVDL 211_ HTVHF 216_ IYHLP 221_SAQAG
1: Endoplasmic reticulum (ER)-membrane-bound lysine N-acetyltransferase catalyzing the N6-acetylation of lysine residues in the lumen of the ER in various proteins, including PROM1 and BACE1, using acetyl-CoA as acetyl donor (PubMed:19011241, PubMed:22267734, PubMed:24556617, PubMed:31945187). Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1 (PubMed:24556617). Acetylates and stabilizes BACE1 immature protein, leading to increased steady-state levels in neurons. By acting on BACE1 expression, may regulate amyloid beta-peptide formation (PubMed:19011241, PubMed:22267734). N(6)-lysine acetylation in ER maintains protein homeostasis and regulates reticulophagy (By similarity)