Large neutral amino acids transporter small subunit 2 (L-type amino acid transporter 2) (hLAT2) (Solute carrier family 7 member 8)
1_MEEGA 6_ RHRNN 11_ TEKKH 16_ PGGGE 21_ SDASP 26_ EAGSG 31_ GGGVA 36_ LKKEI 41_ GLVSA 46_ CGIIV 51_ GNIIG 56_ SGIFV 61_ SPKGV 66_ LENAG 71_ SVGLA 76_ LIVWI 81_ VTGFI 86_ TVVGA 91_ LCYAE 96_ LGVTI 101_ PKSGG 106_ DYSYV 111_ KDIFG 116_ GLAGF 121_ LRLWI 126_ AVLVI 131_ YPTNQ 136_ AVIAL 141_ TFSNY 146_ VLQPL 151_ FPTCF 156_ PPESG 161_ LRLLA 166_ AICLL 171_ LLTWV 176_ NCSSV 181_ RWATR 186_ VQDIF 191_ TAGKL 196_ LALAL 201_ IIIMG 206_ IVQIC 211_ KGEYF 216_ WLEPK 221_ NAFEN 226_ FQEPD 231_ IGLVA 236_ LAFLQ 241_ GSFAY 246_ GGWNF 251_ LNYVT 256_ EELVD 261_ PYKNL 266_ PRAIF 271_ ISIPL 276_ VTFVY 281_ VFANV 286_ AYVTA 291_ MSPQE 296_ LLASN 301_ AVAVT 306_ FGEKL 311_ LGVMA 316_ WIMPI 321_ SVALS 326_ TFGGV 331_ NGSLF 336_ TSSRL 341_ FFAGA 346_ REGHL 351_ PSVLA 356_ MIHVK 361_ RCTPI 366_ PALLF 371_ TCIST 376_ LLMLV 381_ TSDMY 386_ TLINY 391_ VGFIN 396_ YLFYG 401_ VTVAG 406_ QIVLR 411_ WKKPD 416_ IPRPI 421_ KINLL 426_ FPIIY 431_ LLFWA 436_ FLLVF 441_ SLWSE 446_ PVVCG 451_ IGLAI 456_ MLTGV 461_ PVYFL 466_ GVYWQ 471_ HKPKC 476_ FSDFI 481_ ELLTL 486_ VSQKM 491_ CVVVY 496_ PEVER 501_ GSGTE 506_ EANED 511_ MEEQQ 516_ QPMYQ 521_ PTPTK 526_DKDVA
1: Associates with SLC3A2 to form a functional heterodimeric complex that translocates small and large neutral amino acids with broad specificity and a stoichiometry of 1:1. Functions as amino acid antiporter mediating the influx of extracellular essential amino acids mainly in exchange with the efflux of highly concentrated intracellular amino acids (PubMed:10391915, PubMed:11311135, PubMed:11847106, PubMed:12716892, PubMed:15081149, PubMed:15918515, PubMed:29355479, PubMed:33298890, PubMed:34848541). Has relatively symmetrical selectivities but strongly asymmetrical substrate affinities at both the intracellular and extracellular sides of the transporter (PubMed:11847106). This asymmetry allows SLC7A8 to regulate intracellular amino acid pools (mM concentrations) by exchange with external amino acids (uM concentration range), equilibrating the relative concentrations of different amino acids across the plasma membrane instead of mediating their net uptake (PubMed:10391915, PubMed:11847106). May play an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney (PubMed:12716892). Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity (PubMed:12117417). Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane (PubMed:15769744). Imports the thyroid hormone diiodothyronine (T2) and to a smaller extent triiodothyronine (T3) but not rT 3 or thyroxine (T4) (By similarity). Mediates the uptake of L-DOPA (By similarity). May participate in auditory function (By similarity)