Probable ATP-dependent RNA helicase DDX20 (EC 3.6.1.15) (EC 3.6.4.13) (Component of gems 3) (DEAD box protein 20) (DEAD box protein DP 103) (Gemin-3)
1_MAAAF 6_ EASGA 11_ LAAVA 16_ TAMPA 21_ EHVAV 26_ QVPAP 31_ EPTPG 36_ PVRIL 41_ RTAQD 46_ LSSPR 51_ TRTGD 56_ VLLAE 61_ PADFE 66_ SLLLS 71_ RPVLE 76_ GLRAA 81_ GFERP 86_ SPVQL 91_ KAIPL 96_ GRCGL 101_ DLIVQ 106_ AKSGT 111_ GKTCV 116_ FSTIA 121_ LDSLV 126_ LENLS 131_ TQILI 136_ LAPTR 141_ EIAVQ 146_ IHSVI 151_ TAIGI 156_ KMEGL 161_ ECHVF 166_ IGGTP 171_ LSQDK 176_ TRLKK 181_ CHIAV 186_ GSPGR 191_ IKQLI 196_ ELDYL 201_ NPGSI 206_ RLFIL 211_ DEADK 216_ LLEEG 221_ SFQEQ 226_ INWIY 231_ SSLPA 236_ SKQML 241_ AVSAT 246_ YPEFL 251_ ANALT 256_ KYMRD 261_ PTFVR 266_ LNSSD 271_ PSLIG 276_ LKQYY 281_ KVVNS 286_ YPLAH 291_ KVFEE 296_ KTQHL 301_ QELFS 306_ RIPFN 311_ QALVF 316_ SNLHS 321_ RAQHL 326_ ADILS 331_ SKGFP 336_ AECIS 341_ GNMNQ 346_ NQRLD 351_ AMAKL 356_ KHFHC 361_ RVLIS 366_ TDLTS 371_ RGIDA 376_ EKVNL 381_ VVNLD 386_ VPLDW 391_ ETYMH 396_ RIGRA 401_ GRFGT 406_ LGLTV 411_ TYCCR 416_ GEEEN 421_ MMMRI 426_ AQKCN 431_ INLLP 436_ LPDPI 441_ PSGLM 446_ EECVD 451_ WDVEV 456_ KAAVH 461_ TYGIA 466_ SVPNQ 471_ PLKKQ 476_ IQKIE 481_ RTLQI 486_ QKAHG 491_ DHMAS 496_ SRNNS 501_ VSGLS 506_ VKSKN 511_ NTKQK 516_ LPVKS 521_ HSECG 526_ IIEKA 531_ TSPKE 536_ LGCDR 541_ QSEEQ 546_ MKNSV 551_ QTPVE 556_ NSTNS 561_ QHQVK 566_ EALPV 571_ SLPQI 576_ PCLSS 581_ FKIHQ 586_ PYTLT 591_ FAELV 596_ EDYEH 601_ YIKEG 606_ LEKPV 611_ EIIRH 616_ YTGPG 621_ DQTVN 626_ PQNGF 631_ VRNKV 636_ IEQRV 641_ PVLAS 646_ SSQSG 651_ DSESD 656_ SDSYS 661_ SRTSS 666_ QSKGN 671_ KSYLE 676_ GSSDN 681_ QLKDS 686_ ESTPV 691_ DDRIS 696_ LEQPP 701_ NGSDT 706_ PNPEK 711_ YQESP 716_ GIQMK 721_ TRLKE 726_ GASQR 731_ AKQSR 736_ RNLPR 741_ RSSFR 746_ LQTEA 751_ QEDDW 756_ YDCHR 761_ EIRLS 766_ FSDTY 771_ QDYEE 776_ YWRAY 781_ YRAWQ 786_ EYYAA 791_ ASHSY 796_ YWNAQ 801_ RHPSW 806_ MAAYH 811_ MNTIY 816_LQEMM
1: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs)