A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAM-TS 1) (ADAM-TS1) (ADAMTS-1) (EC 3.4.24.-) (METH-1)
1_MQRAV 6_ PEGFG 11_ RRKLG 16_ SDMGN 21_ AERAP 26_ GSRSF 31_ GPVPT 36_ LLLLA 41_ AALLA 46_ VSDAL 51_ GRPSE 56_ EDEEL 61_ VVPEL 66_ ERAPG 71_ HGTTR 76_ LRLHA 81_ FDQQL 86_ DLELR 91_ PDSSF 96_ LAPGF 101_ TLQNV 106_ GRKSG 111_ SETPL 116_ PETDL 121_ AHCFY 126_ SGTVN 131_ GDPSS 136_ AAALS 141_ LCEGV 146_ RGAFY 151_ LLGEA 156_ YFIQP 161_ LPAAS 166_ ERLAT 171_ AAPGE 176_ KPPAP 181_ LQFHL 186_ LRRNR 191_ QGDVG 196_ GTCGV 201_ VDDEP 206_ RPTGK 211_ AETED 216_ EDEGT 221_ EGEDE 226_ GAQWS 231_ PQDPA 236_ LQGVG 241_ QPTGT 246_ GSIRK 251_ KRFVS 256_ SHRYV 261_ ETMLV 266_ ADQSM 271_ AEFHG 276_ SGLKH 281_ YLLTL 286_ FSVAA 291_ RLYKH 296_ PSIRN 301_ SVSLV 306_ VVKIL 311_ VIHDE 316_ QKGPE 321_ VTSNA 326_ ALTLR 331_ NFCNW 336_ QKQHN 341_ PPSDR 346_ DAEHY 351_ DTAIL 356_ FTRQD 361_ LCGSQ 366_ TCDTL 371_ GMADV 376_ GTVCD 381_ PSRSC 386_ SVIED 391_ DGLQA 396_ AFTTA 401_ HELGH 406_ VFNMP 411_ HDDAK 416_ QCASL 421_ NGVNQ 426_ DSHMM 431_ ASMLS 436_ NLDHS 441_ QPWSP 446_ CSAYM 451_ ITSFL 456_ DNGHG 461_ ECLMD 466_ KPQNP 471_ IQLPG 476_ DLPGT 481_ SYDAN 486_ RQCQF 491_ TFGED 496_ SKHCP 501_ DAAST 506_ CSTLW 511_ CTGTS 516_ GGVLV 521_ CQTKH 526_ FPWAD 531_ GTSCG 536_ EGKWC 541_ INGKC 546_ VNKTD 551_ RKHFD 556_ TPFHG 561_ SWGMW 566_ GPWGD 571_ CSRTC 576_ GGGVQ 581_ YTMRE 586_ CDNPV 591_ PKNGG 596_ KYCEG 601_ KRVRY 606_ RSCNL 611_ EDCPD 616_ NNGKT 621_ FREEQ 626_ CEAHN 631_ EFSKA 636_ SFGSG 641_ PAVEW 646_ IPKYA 651_ GVSPK 656_ DRCKL 661_ ICQAK 666_ GIGYF 671_ FVLQP 676_ KVVDG 681_ TPCSP 686_ DSTSV 691_ CVQGQ 696_ CVKAG 701_ CDRII 706_ DSKKK 711_ FDKCG 716_ VCGGN 721_ GSTCK 726_ KISGS 731_ VTSAK 736_ PGYHD 741_ IITIP 746_ TGATN 751_ IEVKQ 756_ RNQRG 761_ SRNNG 766_ SFLAI 771_ KAADG 776_ TYILN 781_ GDYTL 786_ STLEQ 791_ DIMYK 796_ GVVLR 801_ YSGSS 806_ AALER 811_ IRSFS 816_ PLKEP 821_ LTIQV 826_ LTVGN 831_ ALRPK 836_ IKYTY 841_ FVKKK 846_ KESFN 851_ AIPTF 856_ SAWVI 861_ EEWGE 866_ CSKSC 871_ ELGWQ 876_ RRLVE 881_ CRDIN 886_ GQPAS 891_ ECAKE 896_ VKPAS 901_ TRPCA 906_ DHPCP 911_ QWQLG 916_ EWSSC 921_ SKTCG 926_ KGYKK 931_ RSLKC 936_ LSHDG 941_ GVLSH 946_ ESCDP 951_ LKKPK 956_ HFIDF 961_CTMAE
1: Metalloprotease which cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover (By similarity). Also cleaves COMP (PubMed:39672391). Has angiogenic inhibitor activity (PubMed:10438512). May play a critical role in follicular rupture (By similarity)