Cell surface hyaluronidase (EC 3.2.1.35) (Cell migration-inducing hyaluronidase 2) (Transmembrane protein 2)
1_MYATD 6_ SRGHS 11_ PAFLQ 16_ PQNGN 21_ SRHPS 26_ GYVPG 31_ KVVPL 36_ RPPPP 41_ PKSQA 46_ SAKFT 51_ SIRRE 56_ DRATF 61_ AFSPE 66_ EQQAQ 71_ RESQK 76_ QKRHK 81_ NTFIC 86_ FAITS 91_ FSFFI 96_ ALAII 101_ LGISS 106_ KYAPD 111_ ENCPD 116_ QNPRL 121_ RNWDP 126_ GQDSA 131_ KQVVI 136_ KEGDM 141_ LRLTS 146_ DATVH 151_ SIVIQ 156_ DGGLL 161_ VFGDN 166_ KDGSR 171_ NITLR 176_ THYIL 181_ IQDGG 186_ ALHIG 191_ AEKCR 196_ YKSKA 201_ TITLY 206_ GKSDE 211_ GESMP 216_ TFGKK 221_ FIGVE 226_ AGGTL 231_ ELHGA 236_ RKASW 241_ TLLAR 246_ TLNSS 251_ GLPFG 256_ SYTFE 261_ KDFSR 266_ GLNVR 271_ VIDQD 276_ TAKIL 281_ ESERF 286_ DTHEY 291_ RNESR 296_ RLQEF 301_ LRFQD 306_ PGRIV 311_ AIAVG 316_ DSAAK 321_ SLLQG 326_ TIQMI 331_ QERLG 336_ SELIQ 341_ GLGYR 346_ QAWAL 351_ VGVID 356_ GGSTS 361_ CNESV 366_ RNYEN 371_ HSSGG 376_ KALAQ 381_ REFYT 386_ VDGQK 391_ FSVTA 396_ YSEWI 401_ EGVSL 406_ SGFRV 411_ EVVDG 416_ VKLNL 421_ LDDVS 426_ SWKPG 431_ DQIVV 436_ ASTDY 441_ SMYQA 446_ EEFTL 451_ LPCSE 456_ CSHFQ 461_ VKVKE 466_ TPQFL 471_ HMGEI 476_ IDGVD 481_ MRAEV 486_ GILTR 491_ NIVIQ 496_ GEVED 501_ SCYAE 506_ NQCQF 511_ FDYDT 516_ FGGHI 521_ MIMKN 526_ FTSVH 531_ LSYVE 536_ LKHMG 541_ QQQMG 546_ RYPVH 551_ FHLCG 556_ DVDYK 561_ GGYRH 566_ ATFVD 571_ GLSIH 576_ HSFSR 581_ CITVH 586_ GTNGL 591_ LIKDT 596_ IGFDT 601_ LGHCF 606_ FLEDG 611_ IEQRN 616_ TLFHN 621_ LGLLT 626_ KPGTL 631_ LPTDR 636_ NNSMC 641_ TTMRD 646_ KVFGN 651_ YIPVP 656_ ATDCM 661_ AVSTF 666_ WIAHP 671_ NNNLI 676_ NNAAA 681_ GSQDA 686_ GIWYL 691_ FHKEP 696_ TGESS 701_ GLQLL 706_ AKPEL 711_ TPLGI 716_ FYNNR 721_ VHSNF 726_ KAGLF 731_ IDKGV 736_ KTTNS 741_ SAADP 746_ REYLC 751_ LDNSA 756_ RFRPH 761_ QDANP 766_ EKPRV 771_ AALID 776_ RLIAF 781_ KNNDN 786_ GAWVR 791_ GGDII 796_ VQNSA 801_ FADNG 806_ IGLTF 811_ ASDGS 816_ FPSDE 821_ GSSQE 826_ VSESL 831_ FVGES 836_ RNYGF 841_ QGGQN 846_ KYVGT 851_ GGIDQ 856_ KPRTL 861_ PRNRT 866_ FPIRG 871_ FQIYD 876_ GPIHL 881_ TRSTF 886_ KKYVP 891_ TPDRY 896_ SSAIG 901_ FLMKN 906_ SWQIT 911_ PRNNI 916_ SLVKF 921_ GPHVS 926_ LNVFF 931_ GKPGP 936_ WFEDC 941_ EMDGD 946_ KNSIF 951_ HDIDG 956_ SVTGY 961_ KDAYV 966_ GRMDN 971_ YLIRH 976_ PSCVN 981_ VSKWN 986_ AVICS 991_ GTYAQ 996_ VYVQT 1001_ WSTQN 1006_ LSMTI 1011_ TRDEY 1016_ PSNPM 1021_ VLRGI 1026_ NQKAA 1031_ FPQYQ 1036_ PVVML 1041_ EKGYT 1046_ IHWNG 1051_ PAPRT 1056_ TFLYL 1061_ VNFNK 1066_ NDWIR 1071_ VGLCY 1076_ PSNTS 1081_ FQVTF 1086_ GYLQR 1091_ QNGSL 1096_ SKIEE 1101_ YEPVH 1106_ SLEEL 1111_ QRKQS 1116_ ERKFY 1121_ FDSST 1126_ GLLFL 1131_ YLKAK 1136_ SHRHG 1141_ HSYCS 1146_ SQGCE 1151_ RVKIQ 1156_ AATDS 1161_ KDISN 1166_ CMAKA 1171_ YPQYY 1176_ RKPSV 1181_ VKRMP 1186_ AMLTG 1191_ LCQGC 1196_ GTRQV 1201_ VFTSD 1206_ PHKSY 1211_ LPVQF 1216_ QSPDK 1221_ AETQR 1226_ GDPSV 1231_ ISVNG 1236_ TDFTF 1241_ RSAGV 1246_ LLLVV 1251_ DPCSV 1256_ PFRLT 1261_ EKTVF 1266_ PLADV 1271_ SRIEE 1276_ YLKTG 1281_ IPPRS 1286_ IVLLS 1291_ TRGEI 1296_ KQLNI 1301_ SHLLV 1306_ PLGLA 1311_ KPAHL 1316_ YDKGS 1321_ TIFLG 1326_ FSGNF 1331_ KPSWT 1336_ KLFTS 1341_ PAGQG 1346_ LGVLE 1351_ QFIPL 1356_ QLDEY 1361_ GCPRA 1366_ TTVRR 1371_ RDLEL 1376_LKQAS
1: Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 10-5 kDa fragments (PubMed:37527776). Very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate. Has an essential function in systemic hyaluronan catabolism and turnover and regulates cell adhesion and migration via hyaluronan degradation at focal adhesion sites (By similarity). Acts as a regulator of angiogenesis and heart morphogenesis by mediating degradation of extracellular hyaluronan, thereby regulating VEGF signaling (By similarity)