Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (USP on chromosome 21) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25)
1_MTVEQ 6_ NVLQQ 11_ SAAQK 16_ HQQTF 21_ LNQLR 26_ EITGI 31_ NDTQI 36_ LQQAL 41_ KDSNG 46_ NLELA 51_ VAFLT 56_ AKNAK 61_ TPQQE 66_ ETTYY 71_ QTALP 76_ GNDRY 81_ ISVGS 86_ QADTN 91_ VIDLT 96_ GDDKD 101_ DLQRA 106_ IALSL 111_ AESNR 116_ AFRET 121_ GITDE 126_ EQAIS 131_ RVLEA 136_ SIAEN 141_ KACLK 146_ RTPTE 151_ VWRDS 156_ RNPYD 161_ RKRQD 166_ KAPVG 171_ LKNVG 176_ NTCWF 181_ SAVIQ 186_ SLFNL 191_ LEFRR 196_ LVLNY 201_ KPPSN 206_ AQDLP 211_ RNQKE 216_ HRNLP 221_ FMREL 226_ RYLFA 231_ LLVGT 236_ KRKYV 241_ DPSRA 246_ VEILK 251_ DAFKS 256_ NDSQQ 261_ QDVSE 266_ FTHKL 271_ LDWLE 276_ DAFQM 281_ KAEEE 286_ TDEEK 291_ PKNPM 296_ VELFY 301_ GRFLA 306_ VGVLE 311_ GKKFE 316_ NTEMF 321_ GQYPL 326_ QVNGF 331_ KDLHE 336_ CLEAA 341_ MIEGE 346_ IESLH 351_ SENSG 356_ KSGQE 361_ HWFTE 366_ LPPVL 371_ TFELS 376_ RFEFN 381_ QALGR 386_ PEKIH 391_ NKLEF 396_ PQVLY 401_ LDRYM 406_ HRNRE 411_ ITRIK 416_ REEIK 421_ RLKDY 426_ LTVLQ 431_ QRLER 436_ YLSYG 441_ SGPKR 446_ FPLVD 451_ VLQYA 456_ LEFAS 461_ SKPVC 466_ TSPVD 471_ DIDAS 476_ SPPSG 481_ SIPSQ 486_ TLPST 491_ TEQQG 496_ ALSSE 501_ LPSTS 506_ PSSVA 511_ AISSR 516_ SVIHK 521_ PFTQS 526_ RIPPD 531_ LPMHP 536_ APRHI 541_ TEEEL 546_ SVLES 551_ CLHRW 556_ RTEIE 561_ NDTRD 566_ LQESI 571_ SRIHR 576_ TIELM 581_ YSDKS 586_ MIQVP 591_ YRLHA 596_ VLVHE 601_ GQANA 606_ GHYWA 611_ YIFDH 616_ RESRW 621_ MKYND 626_ IAVTK 631_ SSWEE 636_ LVRDS 641_ FGGYR 646_ NASAY 651_ CLMYI 656_ NDKAQ 661_ FLIQE 666_ EFNKE 671_ TGQPL 676_ VGIET 681_ LPPDL 686_ RDFVE 691_ EDNQR 696_ FEKEL 701_ EEWDA 706_ QLAQK 711_ ALQEK 716_ LLASQ 721_ KLRES 726_ ETSVT 731_ TAQAA 736_ GDPEY 741_ LEQPS 746_ RSDFS 751_ KHLKE 756_ ETIQI 761_ ITKAS 766_ HEHED 771_ KSPET 776_ VLQSA 781_ IKLEY 786_ ARLVK 791_ LAQED 796_ TPPET 801_ DYRLH 806_ HVVVY 811_ FIQNQ 816_ APKKI 821_ IEKTL 826_ LEQFG 831_ DRNLS 836_ FDERC 841_ HNIMK 846_ VAQAK 851_ LEMIK 856_ PEEVN 861_ LEEYE 866_ EWHQD 871_ YRKFR 876_ ETTMY 881_ LIIGL 886_ ENFQR 891_ ESYID 896_ SLLFL 901_ ICAYQ 906_ NNKEL 911_ LSKGL 916_ YRGHD 921_ EELIS 926_ HYRRE 931_ CLLKL 936_ NEQAA 941_ ELFES 946_ GEDRE 951_ VNNGL 956_ IIMNE 961_ FIVPF 966_ LPLLL 971_ VDEME 976_ EKDIL 981_ AVEDM 986_ RNRWC 991_ SYLGQ 996_ EMEPH 1001_ LQEKL 1006_ TDFLP 1011_ KLLDC 1016_ SMEIK 1021_ SFHEP 1026_ PKLPS 1031_ YSTHE 1036_ LCERF 1041_ ARIML 1046_SLSRT
1: Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions in various biological processes including inflammation and immune response (PubMed:29518389, PubMed:37683630). Modulates the Wnt/beta-catenin pathway by deubiquitinating and stabilizing tankyrases TNKS1 and TNKS2 (PubMed:28619731, PubMed:30926243, PubMed:38875478). Regulates KEAP1-NRF2 axis in the defense against oxidative assaults by deubiquitinating KEAP1 and protecting it from degradation leading to degradation of the NRF2 transcription factor that is responsible for mounting an anti-oxidation gene expression program (PubMed:37339955). Positively regulates RNA virus-induced innate signaling by interacting with and deubiquitinating ERLIN1 and ERLIN2 (PubMed:37683630). In turn, restricts virus production by regulating cholesterol biosynthetic flux (PubMed:37683630). Acts as a negative regulator of interleukin-17-mediated signaling and inflammation through the removal of 'Lys-63'-linked ubiquitination of TRAF5 and TRAF6 (PubMed:23042150). Prevents the ubiquitination and degradation of TRAF3 to reduce the phosphorylation levels of JNK and P38, the secretion of IL-1B and to induce endotoxin tolerance (PubMed:30579117)
2: The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function