SERTA domain-containing protein 1 (CDK4-binding protein p34SEI1) (SEI-1) (p34(SEI-1)) (Transcriptional regulator interacting with the PHD-bromodomain 1) (TRIP-Br1)
1_MLSKG 6_ LKRKR 11_ EEEEE 16_ KEPLA 21_ VDSWW 26_ LDPGH 31_ TAVAQ 36_ APPAV 41_ ASSSL 46_ FDLSV 51_ LKLHH 56_ SLQQS 61_ EPDLR 66_ HLVLV 71_ VNTLR 76_ RIQAS 81_ MAPAA 86_ ALPPV 91_ PSPPA 96_ APSVA 101_ DNLLA 106_ SSDAA 111_ LSASM 116_ ASLLE 121_ DLSHI 126_ EGLSQ 131_ APQPL 136_ ADEGP 141_ PGRSI 146_ GGAAP 151_ SLGAL 156_ DLLGP 161_ ATGCL 166_ LDDGL 171_ EGLFE 176_ DIDTS 181_ MYDNE 186_ LWAPA 191_ SEGLK 196_ PGPED 201_ GPGKE 206_ EAPEL 211_ DEAEL 216_ DYLMD 221_ VLVGT 226_ QALER 231_PPGPG
1: Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of CDKN2A/p16INK4A