Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1)
1_MATAT 6_ IALQV 11_ NGQQG 16_ GGSEP 21_ AAAAA 26_ VVAAG 31_ DKWKP 36_ PQGTD 41_ SIKME 46_ NGQST 51_ AAKLG 56_ LPPLT 61_ PEQQE 66_ ALQKA 71_ KKYAM 76_ EQSIK 81_ SVLVK 86_ QTIAH 91_ QQQQL 96_ TNLQM 101_ AAVTM 106_ GFGDP 111_ LSPLQ 116_ SMAAQ 121_ RQRAL 126_ AIMCR 131_ VYVGS 136_ IYYEL 141_ GEDTI 146_ RQAFA 151_ PFGPI 156_ KSIDM 161_ SWDSV 166_ TMKHK 171_ GFAFV 176_ EYEVP 181_ EAAQL 186_ ALEQM 191_ NSVML 196_ GGRNI 201_ KVGRP 206_ SNIGQ 211_ AQPII 216_ DQLAE 221_ EARAF 226_ NRIYV 231_ ASVHQ 236_ DLSDD 241_ DIKSV 246_ FEAFG 251_ KIKSC 256_ TLARD 261_ PTTGK 266_ HKGYG 271_ FIEYE 276_ KAQSS 281_ QDAVS 286_ SMNLF 291_ DLGGQ 296_ YLRVG 301_ KAVTP 306_ PMPLL 311_ TPATP 316_ GGLPP 321_ AAAVA 326_ AAAAT 331_ AKITA 336_ QEAVA 341_ GAAVL 346_ GTLGT 351_ PGLVS 356_ PALTL 361_ AQPLG 366_ TLPQA 371_ VMAAQ 376_ APGVI 381_ TGVTP 386_ ARPPI 391_ PVTIP 396_ SVGVV 401_ NPILA 406_ SPPTL 411_ GLLEP 416_ KKEKE 421_ EEELF 426_ PESER 431_ PEMLS 436_ EQEHM 441_ SISGS 446_ SARHM 451_ VMQKL 456_ LRKQE 461_ STVMV 466_ LRNMV 471_ DPKDI 476_ DDDLE 481_ GEVTE 486_ ECGKF 491_ GAVNR 496_ VIIYQ 501_ EKQGE 506_ EEDAE 511_ IIVKI 516_ FVEFS 521_ IASET 526_ HKAIQ 531_ ALNGR 536_ WFAGR 541_ KVVAE 546_ VYDQE 551_RFDNS
1: DNA- and RNA-binding protein, involved in several nuclear processes such as pre-mRNA splicing, apoptosis and transcription regulation. In association with FUBP1 regulates MYC transcription at the P2 promoter through the core-TFIIH basal transcription factor. Acts as a transcriptional repressor through the core-TFIIH basal transcription factor. Represses FUBP1-induced transcriptional activation but not basal transcription. Decreases ERCC3 helicase activity. Does not repress TFIIH-mediated transcription in xeroderma pigmentosum complementation group B (XPB) cells. Is also involved in pre-mRNA splicing. Promotes splicing of an intron with weak 3'-splice site and pyrimidine tract in a cooperative manner with U2AF2. Involved in apoptosis induction when overexpressed in HeLa cells. Isoform 6 failed to repress MYC transcription and inhibited FIR-induced apoptosis in colorectal cancer. Isoform 6 may contribute to tumor progression by enabling increased MYC expression and greater resistance to apoptosis in tumors than in normal cells. Modulates alternative splicing of several mRNAs. Binds to relaxed DNA of active promoter regions. Binds to the pyrimidine tract and 3'-splice site regions of pre-mRNA; binding is enhanced in presence of U2AF2. Binds to Y5 RNA in association with RO60. Binds to poly(U) RNA