Translation initiation factor eIF-2B subunit delta (eIF-2B GDP-GTP exchange factor subunit delta)
1_MAAVA 6_ VAVRE 11_ DSGSG 16_ MKAEL 21_ PPGPG 26_ AVGRE 31_ MTKEE 36_ KLQLR 41_ KEKKQ 46_ QKKKR 51_ KEEKG 56_ AEPET 61_ GSAVS 66_ AAQCQ 71_ VGPTR 76_ ELPES 81_ GIQLG 86_ TPREK 91_ VPAGR 96_ SKAEL 101_ RAERR 106_ AKQEA 111_ ERALK 116_ QARKG 121_ EQGGP 126_ PPKAS 131_ PSTAG 136_ ETPSG 141_ VKRLP 146_ EYPQV 151_ DDLLL 156_ RRLVK 161_ KPERQ 166_ QVPTR 171_ KDYGS 176_ KVSLF 181_ SHLPQ 186_ YSRQN 191_ SLTQF 196_ MSIPS 201_ SVIHP 206_ AMVRL 211_ GLQYS 216_ QGLVS 221_ GSNAR 226_ CIALL 231_ RALQQ 236_ VIQDY 241_ TTPPN 246_ EELSR 251_ DLVNK 256_ LKPYM 261_ SFLTQ 266_ CRPLS 271_ ASMHN 276_ AIKFL 281_ NKEIT 286_ SVGSS 291_ KREEE 296_ AKSEL 301_ RAAID 306_ RYVQE 311_ KIVLA 316_ AQAIS 321_ RFAYQ 326_ KISNG 331_ DVILV 336_ YGCSS 341_ LVSRI 346_ LQEAW 351_ TEGRR 356_ FRVVV 361_ VDSRP 366_ WLEGR 371_ HTLRS 376_ LVHAG 381_ VPASY 386_ LLIPA 391_ ASYVL 396_ PEVSK 401_ VLLGA 406_ HALLA 411_ NGSVM 416_ SRVGT 421_ AQLAL 426_ VARAH 431_ NVPVL 436_ VCCET 441_ YKFCE 446_ RVQTD 451_ AFVSN 456_ ELDDP 461_ DDLQC 466_ KRGEH 471_ VALAN 476_ WQNHA 481_ SLRLL 486_ NLVYD 491_ VTPPE 496_ LVDLV 501_ ITELG 506_ MIPCS 511_ SVPVV 516_LRVKS
1: Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit (PubMed:25858979, PubMed:27023709, PubMed:31048492). Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed (PubMed:25858979, PubMed:31048492)