Importin-11 (Imp11) (Ran-binding protein 11) (RanBP11)
1_MDLNS 6_ ASTVV 11_ LQVLT 16_ QATSQ 21_ DTAVL 26_ KPAEE 31_ QLKQW 36_ ETQPG 41_ FYSVL 46_ LNIFT 51_ NHTLD 56_ INVRW 61_ LAVLY 66_ FKHGI 71_ DRYWR 76_ RVAPH 81_ ALSEE 86_ EKTTL 91_ RAGLI 96_ TNFNE 101_ PINQI 106_ ATQIA 111_ VLIAK 116_ VARLD 121_ CPRQW 126_ PELIP 131_ TLIES 136_ VKVQD 141_ DLRQH 146_ RALLT 151_ FYHVT 156_ KTLAS 161_ KRLAA 166_ DRKLF 171_ YDLAS 176_ GIYNF 181_ ACSLW 186_ NHHTD 191_ TFLQE 196_ VSSGN 201_ EAAIL 206_ SSLER 211_ TLLSL 216_ KVLRK 221_ LTVNG 226_ FVEPH 231_ KNMEV 236_ MGFLH 241_ GIFER 246_ LKQFL 251_ ECSRS 256_ IGTDN 261_ VCRDR 266_ LEKTI 271_ ILFTK 276_ VLLDF 281_ LDQHP 286_ FSFTP 291_ LIQRS 296_ LEFSV 301_ SYVFT 306_ EVGEG 311_ VTFER 316_ FIVQC 321_ MNLIK 326_ MIVKN 331_ YAYKP 336_ SKNFE 341_ DSSPE 346_ TLEAH 351_ KIKMA 356_ FFTYP 361_ TLTEI 366_ CRRLV 371_ SHYFL 376_ LTEEE 381_ LTMWE 386_ EDPEG 391_ FTVEE 396_ TGGDS 401_ WKYSL 406_ RPCTE 411_ VLFID 416_ IFHEY 421_ NQTLT 426_ PVLLE 431_ MMQTL 436_ QGPTN 441_ VEDMN 446_ ALLIK 451_ DAVYN 456_ AVGLA 461_ AYELF 466_ DSVDF 471_ DQWFK 476_ NQLLP 481_ ELQVI 486_ HNRYK 491_ PLRRR 496_ VIWLI 501_ GQWIS 506_ VKFKS 511_ DLRPM 516_ LYEAI 521_ CNLLQ 526_ DQDLV 531_ VRIET 536_ ATTLK 541_ LTVDD 546_ FEFRT 551_ DQFLP 556_ YLETM 561_ FTLLF 566_ QLLQQ 571_ VTECD 576_ TKMHV 581_ LHVLS 586_ CVIER 591_ VNMQI 596_ RPYVG 601_ CLVQY 606_ LPLLW 611_ KQSEE 616_ HNMLR 621_ CAILT 626_ TLIHL 631_ VQGLG 636_ ADSKN 641_ LYPFL 646_ LPVIQ 651_ LSTDV 656_ SQPPH 661_ VYLLE 666_ DGLEL 671_ WLVTL 676_ ENSPC 681_ ITPEL 686_ LRIFQ 691_ NMSPL 696_ LELSS 701_ ENLRT 706_ CFKII 711_ NGYIF 716_ LSSTE 721_ FLQTY 726_ AVGLC 731_ QSFCE 736_ LLKEI 741_ TTEGQ 746_ VQVLK 751_ VVENA 756_ LKVNP 761_ ILGPQ 766_ MFQPI 771_ LPYVF 776_ KGIIE 781_ GERYP 786_ VVMST 791_ YLGVM 796_ GRVLL 801_ QNTSF 806_ FSSLL 811_ NEMAH 816_ KFNQE 821_ MDQLL 826_ GNMIE 831_ MWVDR 836_ MDNIT 841_ QPERR 846_ KLSAL 851_ ALLSL 856_ LPSDN 861_ SVIQD 866_ KFCGI 871_ INISV 876_ EGLHD 881_ VMTED 886_ PETGT 891_ YKDCM 896_ LMSHL 901_ EEPKV 906_ TEDEE 911_ PPTEQ 916_ DKRKK 921_ MLALK 926_ DPVHT 931_ VSLQQ 936_ FIYEK 941_ LKAQQ 946_ EMLGE 951_ QGFQS 956_ LMETV 961_ DTEIV 966_TQLQE
1: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of UBE2E3, and of RPL12 (By similarity)